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Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus.
Zhang N, Chen HM, Koch V, Schmitz H, Liao CL, Bretner M, Bhadti VS, Fattom AI, Naso RB, Hosmane RS, Borowski P. Zhang N, et al. Among authors: hosmane rs. J Med Chem. 2003 Sep 11;46(19):4149-64. doi: 10.1021/jm030842j. J Med Chem. 2003. PMID: 12954067
A novel imidazole nucleoside containing a diaminodihydro-S-triazine as a substituent: inhibitory activity against the West Nile virus NTPase/helicase.
Ujjinamatada RK, Agasimundin YS, Zhang P, Hosmane RS, Schuessler R, Borowski P, Kalicharran K, Fattom A. Ujjinamatada RK, et al. Among authors: hosmane rs. Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1775-88. doi: 10.1080/15257770500267063. Nucleosides Nucleotides Nucleic Acids. 2005. PMID: 16438047
An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-beta-D-ribofuranoside.
Ujjinamatada RK, Baier A, Borowski P, Hosmane RS. Ujjinamatada RK, et al. Among authors: hosmane rs. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2285-8. doi: 10.1016/j.bmcl.2007.01.074. Epub 2007 Jan 27. Bioorg Med Chem Lett. 2007. PMID: 17289387 Free PMC article.
Chemical and biological effects of substitution of the 2-position of ring-expanded ('fat') nucleosides containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system: the role of electronic and steric factors on glycosidic bond stability and anti-HCV activity.
Zhang P, Zhang N, Buckwold VE, Hosmane RS. Zhang P, et al. Among authors: hosmane rs. Bioorg Med Chem. 2007 Jul 15;15(14):4933-45. doi: 10.1016/j.bmc.2007.04.043. Epub 2007 Apr 29. Bioorg Med Chem. 2007. PMID: 17507230 Free PMC article.
57 results