Schleif WA - Search Results

1

Novel HIV-1 protease inhibitors active against multiple PI-resistant viral strains: coadministration with indinavir.

Kevin NJ, Duffy JL, Kirk BA, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Kevin NJ, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4027-30. doi: 10.1016/j.bmcl.2003.08.049. Bioorg Med Chem Lett. 2003. PMID: 14592500

2

Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.

Cheng Y, Zhang F, Rano TA, Lu Z, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Rutkowski CA, Lin JH, Jin L, Emini EA, Chapman KT, Tata JR. Cheng Y, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2419-22. doi: 10.1016/s0960-894x(02)00424-9. Bioorg Med Chem Lett. 2002. PMID: 12161147

3

Synthesis and activity of novel HIV protease inhibitors with improved potency against multiple PI-resistant viral strains.

Duffy JL, Kevin NJ, Kirk BA, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2423-6. doi: 10.1016/s0960-894x(02)00425-0. Bioorg Med Chem Lett. 2002. PMID: 12161148

4

Combinatorial library of indinavir analogues: replacement for the aminoindanol at P2'.

Raghavan S, Yang Z, Mosley RT, Schleif WA, Gabryelski L, Olsen DB, Stahlhut M, Kuo LC, Emini EA, Chapman KT, Tata JR. Raghavan S, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2855-8. doi: 10.1016/s0960-894x(02)00632-7. Bioorg Med Chem Lett. 2002. PMID: 12270162

5

1,3,4-Trisubstituted pyrrolidine CCR5 receptor antagonists. Part 4: synthesis of N-1 acidic functionality affording analogues with enhanced antiviral activity against HIV.

Lynch CL, Hale JJ, Budhu RJ, Gentry AL, Mills SG, Chapman KT, MacCoss M, Malkowitz L, Springer MS, Gould SL, DeMartino JA, Siciliano SJ, Cascieri MA, Carella A, Carver G, Holmes K, Schleif WA, Danzeisen R, Hazuda D, Kessler J, Lineberger J, Miller M, Emini EA. Lynch CL, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2002 Oct 21;12(20):3001-4. doi: 10.1016/s0960-894x(02)00606-6. Bioorg Med Chem Lett. 2002. PMID: 12270193

6

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.

Smith AB 3rd, Cantin LD, Pasternak A, Guise-Zawacki L, Yao W, Charnley AK, Barbosa J, Sprengeler PA, Hirschmann R, Munshi S, Olsen DB, Schleif WA, Kuo LC. Smith AB 3rd, et al. Among authors: schleif wa. J Med Chem. 2003 May 8;46(10):1831-44. doi: 10.1021/jm0204587. J Med Chem. 2003. PMID: 12723947

7

Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus.

Lu Z, Raghavan S, Bohn J, Charest M, Stahlhut MW, Rutkowski CA, Simcoe AL, Olsen DB, Schleif WA, Carella A, Gabryelski L, Jin L, Lin JH, Emini E, Chapman K, Tata JR. Lu Z, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2003 May 19;13(10):1821-4. doi: 10.1016/s0960-894x(03)00262-2. Bioorg Med Chem Lett. 2003. PMID: 12729673

8

HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent.

Duffy JL, Rano TA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2569-72. doi: 10.1016/s0960-894x(03)00475-x. Bioorg Med Chem Lett. 2003. PMID: 12852968

9

The design, synthesis and evaluation of novel HIV-1 protease inhibitors with high potency against PI-resistant viral strains.

Zhang F, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Zhang F, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2573-6. doi: 10.1016/s0960-894x(03)00474-8. Bioorg Med Chem Lett. 2003. PMID: 12852969

10

HIV-1 protease inhibitors with picomolar potency against PI-resistant HIV-1 by modification of the P1' substituent.

Duffy JL, Kirk BA, Kevin NJ, Chapman KT, Schleif WA, Olsen DB, Stahlhut M, Rutkowski CA, Kuo LC, Jin L, Lin JH, Emini EA, Tata JR. Duffy JL, et al. Among authors: schleif wa. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3323-6. doi: 10.1016/s0960-894x(03)00680-2. Bioorg Med Chem Lett. 2003. PMID: 12951118

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