Trudell JR - Search Results

1

Charged residues in the beta2 subunit involved in GABAA receptor activation.

Kash TL, Dizon MJ, Trudell JR, Harrison NL. Kash TL, et al. Among authors: trudell jr. J Biol Chem. 2004 Feb 6;279(6):4887-93. doi: 10.1074/jbc.M311441200. Epub 2003 Nov 10. J Biol Chem. 2004. PMID: 14610076 Free article.

2

Tryptophan scanning mutagenesis in TM4 of the GABA(A) receptor alpha1 subunit: implications for modulation by inhaled anesthetics and ion channel structure.

Jenkins A, Andreasen A, Trudell JR, Harrison NL. Jenkins A, et al. Among authors: trudell jr. Neuropharmacology. 2002 Sep;43(4):669-78. doi: 10.1016/s0028-3908(02)00175-2. Neuropharmacology. 2002. PMID: 12367612

3

Coupling of agonist binding to channel gating in the GABA(A) receptor.

Kash TL, Jenkins A, Kelley JC, Trudell JR, Harrison NL. Kash TL, et al. Among authors: trudell jr. Nature. 2003 Jan 16;421(6920):272-5. doi: 10.1038/nature01280. Nature. 2003. PMID: 12529644

4

Alanine-scanning mutagenesis in the signature disulfide loop of the glycine receptor alpha 1 subunit: critical residues for activation and modulation.

Schofield CM, Trudell JR, Harrison NL. Schofield CM, et al. Among authors: trudell jr. Biochemistry. 2004 Aug 10;43(31):10058-63. doi: 10.1021/bi036159g. Biochemistry. 2004. PMID: 15287733

5

Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors.

Kash TL, Kim T, Trudell JR, Harrison NL. Kash TL, et al. Among authors: trudell jr. Neurosci Lett. 2004 Nov 23;371(2-3):230-4. doi: 10.1016/j.neulet.2004.09.002. Neurosci Lett. 2004. PMID: 15519763

6

Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor.

Kash TL, Trudell JR, Harrison NL. Kash TL, et al. Among authors: trudell jr. Biochem Soc Trans. 2004 Jun;32(Pt3):540-6. doi: 10.1042/BST0320540. Biochem Soc Trans. 2004. PMID: 15157180 Review.

7

A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.

Castaldo P, Stefanoni P, Miceli F, Coppola G, Del Giudice EM, Bellini G, Pascotto A, Trudell JR, Harrison NL, Annunziato L, Taglialatela M. Castaldo P, et al. Among authors: trudell jr. J Biol Chem. 2004 Jun 11;279(24):25598-604. doi: 10.1074/jbc.M311021200. Epub 2004 Apr 5. J Biol Chem. 2004. PMID: 15066993 Free article.

8

Evidence for a common binding cavity for three general anesthetics within the GABAA receptor.

Jenkins A, Greenblatt EP, Faulkner HJ, Bertaccini E, Light A, Lin A, Andreasen A, Viner A, Trudell JR, Harrison NL. Jenkins A, et al. Among authors: trudell jr. J Neurosci. 2001 Mar 15;21(6):RC136. doi: 10.1523/JNEUROSCI.21-06-j0002.2001. J Neurosci. 2001. PMID: 11245705 Free PMC article.

9

Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit.

Trudell JR, Yue ME, Bertaccini EJ, Jenkins A, Harrison NL. Trudell JR, et al. J Chem Inf Model. 2008 Feb;48(2):344-9. doi: 10.1021/ci700324a. Epub 2008 Jan 16. J Chem Inf Model. 2008. PMID: 18197653

10

Emerging molecular mechanisms of general anesthetic action.

Hemmings HC Jr, Akabas MH, Goldstein PA, Trudell JR, Orser BA, Harrison NL. Hemmings HC Jr, et al. Among authors: trudell jr. Trends Pharmacol Sci. 2005 Oct;26(10):503-10. doi: 10.1016/j.tips.2005.08.006. Trends Pharmacol Sci. 2005. PMID: 16126282 Review.

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