Cushman M - Search Results

1

Differential induction of topoisomerase I-DNA cleavage complexes by the indenoisoquinoline MJ-III-65 (NSC 706744) and camptothecin: base sequence analysis and activity against camptothecin-resistant topoisomerases I.

Antony S, Jayaraman M, Laco G, Kohlhagen G, Kohn KW, Cushman M, Pommier Y. Antony S, et al. Among authors: cushman m. Cancer Res. 2003 Nov 1;63(21):7428-35. Cancer Res. 2003. PMID: 14612542

2

Protein-linked DNA strand breaks induced by NSC 314622, a novel noncamptothecin topoisomerase I poison.

Kohlhagen G, Paull KD, Cushman M, Nagafuji P, Pommier Y. Kohlhagen G, et al. Among authors: cushman m. Mol Pharmacol. 1998 Jul;54(1):50-8. doi: 10.1124/mol.54.1.50. Mol Pharmacol. 1998. PMID: 9658189

3

Synthesis of cytotoxic indenoisoquinoline topoisomerase I poisons.

Strumberg D, Pommier Y, Paull K, Jayaraman M, Nagafuji P, Cushman M. Strumberg D, et al. Among authors: cushman m. J Med Chem. 1999 Feb 11;42(3):446-57. doi: 10.1021/jm9803323. J Med Chem. 1999. PMID: 9986716

4

Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.

Cushman M, Jayaraman M, Vroman JA, Fukunaga AK, Fox BM, Kohlhagen G, Strumberg D, Pommier Y. Cushman M, et al. J Med Chem. 2000 Oct 5;43(20):3688-98. doi: 10.1021/jm000029d. J Med Chem. 2000. PMID: 11020283

5

Novel Oxidative Transformation of Indenoisoquinolines to Isoquinoline-3-spiro-3'-phthalides in the Presence of Osmium Tetraoxide and 4-Methylmorpholine N-Oxide.

Jayaraman M, Fanwick PE, Cushman M. Jayaraman M, et al. Among authors: cushman m. J Org Chem. 1998 Aug 21;63(17):5736-5737. doi: 10.1021/jo980928y. J Org Chem. 1998. PMID: 11672165 No abstract available.

6

Synthesis of new dihydroindeno[1,2-c]isoquinoline and indenoisoquinolinium chloride topoisomerase I inhibitors having high in vivo anticancer activity in the hollow fiber animal model.

Jayaraman M, Fox BM, Hollingshead M, Kohlhagen G, Pommier Y, Cushman M. Jayaraman M, et al. Among authors: cushman m. J Med Chem. 2002 Jan 3;45(1):242-9. doi: 10.1021/jm000498f. J Med Chem. 2002. PMID: 11754595

7

Synthesis of substituted diarylmethylenepiperidines (DAMPs), a novel class of anti-HIV agents.

Xu G, Kannan A, Hartman TL, Wargo H, Watson K, Turpin JA, Buckheit RW Jr, Johnson AA, Pommier Y, Cushman M. Xu G, et al. Among authors: cushman m. Bioorg Med Chem. 2002 Aug;10(8):2807-16. doi: 10.1016/s0968-0896(02)00095-0. Bioorg Med Chem. 2002. PMID: 12057671

8

Design, synthesis, and biological evaluation of cytotoxic 11-alkenylindenoisoquinoline topoisomerase I inhibitors and indenoisoquinoline-camptothecin hybrids.

Fox BM, Xiao X, Antony S, Kohlhagen G, Pommier Y, Staker BL, Stewart L, Cushman M. Fox BM, et al. Among authors: cushman m. J Med Chem. 2003 Jul 17;46(15):3275-82. doi: 10.1021/jm0300476. J Med Chem. 2003. PMID: 12852757

9

Design, synthesis, and biological evaluation of indenoisoquinoline topoisomerase I inhibitors featuring polyamine side chains on the lactam nitrogen.

Nagarajan M, Xiao X, Antony S, Kohlhagen G, Pommier Y, Cushman M. Nagarajan M, et al. Among authors: cushman m. J Med Chem. 2003 Dec 18;46(26):5712-24. doi: 10.1021/jm030313f. J Med Chem. 2003. PMID: 14667224

10

Synthesis of nitrated indenoisoquinolines as topoisomerase I inhibitors.

Morrell A, Antony S, Kohlhagen G, Pommier Y, Cushman M. Morrell A, et al. Among authors: cushman m. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3659-63. doi: 10.1016/j.bmcl.2004.05.022. Bioorg Med Chem Lett. 2004. PMID: 15203138

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

1,184 results

Search Page

Filters