Cohen LH - Search Results

1

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates.

van Beek ER, Cohen LH, Leroy IM, Ebetino FH, Löwik CW, Papapoulos SE. van Beek ER, et al. Among authors: cohen lh. Bone. 2003 Nov;33(5):805-11. doi: 10.1016/j.bone.2003.07.007. Bone. 2003. PMID: 14623056

2

Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo.

van Beek E, Pieterman E, Cohen L, Löwik C, Papapoulos S. van Beek E, et al. Biochem Biophys Res Commun. 1999 Feb 16;255(2):491-4. doi: 10.1006/bbrc.1999.0224. Biochem Biophys Res Commun. 1999. PMID: 10049736

3

Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates.

van Beek E, Pieterman E, Cohen L, Löwik C, Papapoulos S. van Beek E, et al. Biochem Biophys Res Commun. 1999 Oct 14;264(1):108-11. doi: 10.1006/bbrc.1999.1499. Biochem Biophys Res Commun. 1999. PMID: 10527849

4

A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1.

El Oualid F, van den Elst H, Leroy IM, Pieterman E, Cohen LH, Burm BE, Overkleeft HS, van der Marel GA, Overhand M. El Oualid F, et al. Among authors: cohen lh. J Comb Chem. 2005 Sep-Oct;7(5):703-13. doi: 10.1021/cc0500203. J Comb Chem. 2005. PMID: 16153065

5

Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.

El Oualid F, Burm BE, Leroy IM, Cohen LH, van Boom JH, van den Elst H, Overkleeft HS, van der Marel GA, Overhand M. El Oualid F, et al. Among authors: cohen lh. J Med Chem. 2004 Jul 29;47(16):3920-3. doi: 10.1021/jm049927q. J Med Chem. 2004. PMID: 15267228

6

Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1.

El Oualid F, Baktawar J, Leroy IM, van den Elst H, Cohen LH, van der Marel GA, Overkleeft HS, Overhand M. El Oualid F, et al. Among authors: cohen lh. Bioorg Med Chem. 2005 Mar 1;13(5):1463-75. doi: 10.1016/j.bmc.2004.12.035. Bioorg Med Chem. 2005. PMID: 15698762

7

Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics.

Cohen LH, Pieterman E, van Leeuwen RE, Overhand M, Burm BE, van der Marel GA, van Boom JH. Cohen LH, et al. Biochem Pharmacol. 2000 Oct 15;60(8):1061-8. doi: 10.1016/s0006-2952(00)00386-5. Biochem Pharmacol. 2000. PMID: 11007942 Review.

8

Cholesterol content of the rat lens is lowered by administration of simvastatin, but not by pravastatin.

De Vries AC, Vermeer MA, Bredman JJ, Bär PR, Cohen LH. De Vries AC, et al. Among authors: cohen lh. Exp Eye Res. 1993 Apr;56(4):393-9. doi: 10.1006/exer.1993.1053. Exp Eye Res. 1993. PMID: 8500554

9

Different analogues of farnesyl pyrophosphate inhibit squalene synthase and protein:farnesyltransferase to different extents.

Cohen LH, Valentijn AR, Roodenburg L, Van Leeuwen RE, Huisman RH, Lutz RJ, Van der Marel GA, Van Boom JH. Cohen LH, et al. Biochem Pharmacol. 1995 Mar 15;49(6):839-45. doi: 10.1016/0006-2952(94)00454-t. Biochem Pharmacol. 1995. PMID: 7702642

10

Differential effect of simvastatin on various signal transduction intermediates in cultured human smooth muscle cells.

Nègre-Aminou P, van Erck M, van Leeuwen RE, Collard JG, Cohen LH. Nègre-Aminou P, et al. Among authors: cohen lh. Biochem Pharmacol. 2001 Apr 15;61(8):991-8. doi: 10.1016/s0006-2952(01)00566-4. Biochem Pharmacol. 2001. PMID: 11286990

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