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DNA oligonucleotide microarray technology identifies fisp-12 among other potential fibrogenic genes following murine unilateral ureteral obstruction (UUO): modulation during epithelial-mesenchymal transition.
Higgins DF, Lappin DW, Kieran NE, Anders HJ, Watson RW, Strutz F, Schlondorff D, Haase VH, Fitzpatrick JM, Godson C, Brady HR. Higgins DF, et al. Kidney Int. 2003 Dec;64(6):2079-91. doi: 10.1046/j.1523-1755.2003.00306.x. Kidney Int. 2003. PMID: 14633130 Free article.
IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses.
Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M. Corcoran JB, et al. Among authors: higgins df. Biochim Biophys Acta. 2013 Aug;1833(8):1969-78. doi: 10.1016/j.bbamcr.2013.03.027. Epub 2013 Apr 6. Biochim Biophys Acta. 2013. PMID: 23567938 Free article.
Lipoxin A₄ and benzo-lipoxin A₄ attenuate experimental renal fibrosis.
Börgeson E, Docherty NG, Murphy M, Rodgers K, Ryan A, O'Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C. Börgeson E, et al. Among authors: higgins df. FASEB J. 2011 Sep;25(9):2967-79. doi: 10.1096/fj.11-185017. Epub 2011 May 31. FASEB J. 2011. PMID: 21628447
Hypoxic induction of Ctgf is directly mediated by Hif-1.
Higgins DF, Biju MP, Akai Y, Wutz A, Johnson RS, Haase VH. Higgins DF, et al. Am J Physiol Renal Physiol. 2004 Dec;287(6):F1223-32. doi: 10.1152/ajprenal.00245.2004. Epub 2004 Aug 17. Am J Physiol Renal Physiol. 2004. PMID: 15315937 Free article.
Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis.
Beaton H, Andrews D, Parsons M, Murphy M, Gaffney A, Kavanagh D, McKay GJ, Maxwell AP, Taylor CT, Cummins EP, Godson C, Higgins DF, Murphy P, Crean J. Beaton H, et al. Among authors: higgins df. Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F35-45. doi: 10.1152/ajprenal.00136.2016. Epub 2016 Apr 27. Am J Physiol Renal Physiol. 2016. PMID: 27122540 Free article.
BMP7-induced-Pten inhibits Akt and prevents renal fibrosis.
Higgins DF, Ewart LM, Masterson E, Tennant S, Grebnev G, Prunotto M, Pomposiello S, Conde-Knape K, Martin FM, Godson C. Higgins DF, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3095-3104. doi: 10.1016/j.bbadis.2017.09.011. Epub 2017 Sep 18. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28923783 Free article.
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