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The Mycobacterium tuberculosis complex-restricted gene cfp32 encodes an expressed protein that is detectable in tuberculosis patients and is positively correlated with pulmonary interleukin-10.
Huard RC, Chitale S, Leung M, Lazzarini LC, Zhu H, Shashkina E, Laal S, Conde MB, Kritski AL, Belisle JT, Kreiswirth BN, Lapa e Silva JR, Ho JL. Huard RC, et al. Among authors: zhu h. Infect Immun. 2003 Dec;71(12):6871-83. doi: 10.1128/IAI.71.12.6871-6883.2003. Infect Immun. 2003. PMID: 14638775 Free PMC article.
Enhanced patient serum immunoreactivity to recombinant Mycobacterium tuberculosis CFP32 produced in the yeast Pichia pastoris compared to Escherichia coli and its potential for serodiagnosis of tuberculosis.
Benabdesselem C, Fathallah DM, Huard RC, Zhu H, Jarboui MA, Dellagi K, Ho JL, Barbouche RM. Benabdesselem C, et al. Among authors: zhu h. J Clin Microbiol. 2006 Sep;44(9):3086-93. doi: 10.1128/JCM.02672-05. J Clin Microbiol. 2006. PMID: 16954231 Free PMC article.
Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity.
Almeida AS, Lago PM, Boechat N, Huard RC, Lazzarini LC, Santos AR, Nociari M, Zhu H, Perez-Sweeney BM, Bang H, Ni Q, Huang J, Gibson AL, Flores VC, Pecanha LR, Kritski AL, Lapa e Silva JR, Ho JL. Almeida AS, et al. Among authors: zhu h. J Immunol. 2009 Jul 1;183(1):718-31. doi: 10.4049/jimmunol.0801212. Epub 2009 Jun 17. J Immunol. 2009. PMID: 19535630
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