Creighton DJ - Search Results

1

Glyoxalase I inhibitors in cancer chemotherapy.

Creighton DJ, Zheng ZB, Holewinski R, Hamilton DS, Eiseman JL. Creighton DJ, et al. Biochem Soc Trans. 2003 Dec;31(Pt 6):1378-82. doi: 10.1042/bst0311378. Biochem Soc Trans. 2003. PMID: 14641067 Review.

2

N-(2-hydroxypropyl)methacrylamide copolymers of a glutathione (GSH)-activated glyoxalase i inhibitor and DNA alkylating agent: synthesis, reaction kinetics with GSH, and in vitro antitumor activities.

Zheng ZB, Zhu G, Tak H, Joseph E, Eiseman JL, Creighton DJ. Zheng ZB, et al. Among authors: creighton dj. Bioconjug Chem. 2005 May-Jun;16(3):598-607. doi: 10.1021/bc0499634. Bioconjug Chem. 2005. PMID: 15898727

3

Inhibition by active site directed covalent modification of human glyoxalase I.

Holewinski RJ, Creighton DJ. Holewinski RJ, et al. Among authors: creighton dj. Bioorg Med Chem. 2014 Jul 1;22(13):3301-8. doi: 10.1016/j.bmc.2014.04.055. Epub 2014 May 6. Bioorg Med Chem. 2014. PMID: 24856185 Free article.

4

Caution: the glycylmethyl and glycylethyl esters of glutathione are substrates for glyoxalase I.

Hamilton DS, Creighton DJ. Hamilton DS, et al. Among authors: creighton dj. Biochim Biophys Acta. 1992 Sep 23;1159(2):203-8. doi: 10.1016/0167-4838(92)90026-a. Biochim Biophys Acta. 1992. PMID: 1390924

5

Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy.

Hamilton DS, Creighton DJ. Hamilton DS, et al. Among authors: creighton dj. J Biol Chem. 1992 Dec 15;267(35):24933-6. J Biol Chem. 1992. PMID: 1459997 Free article.

6

S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II.

Murthy NS, Bakeris T, Kavarana MJ, Hamilton DS, Lan Y, Creighton DJ. Murthy NS, et al. Among authors: creighton dj. J Med Chem. 1994 Jul 8;37(14):2161-6. doi: 10.1021/jm00040a007. J Med Chem. 1994. PMID: 8035422

7

Mechanism-based competitive inhibitors of glyoxalase I: intracellular delivery, in vitro antitumor activities, and stabilities in human serum and mouse serum.

Kavarana MJ, Kovaleva EG, Creighton DJ, Wollman MB, Eiseman JL. Kavarana MJ, et al. Among authors: creighton dj. J Med Chem. 1999 Jan 28;42(2):221-8. doi: 10.1021/jm9708036. J Med Chem. 1999. PMID: 9925727

8

A new method for rapidly generating inhibitors of glyoxalase I inside tumor cells using S-(N-aryl-N-hydroxycarbamoyl)ethylsulfoxides.

Hamilton DS, Kavarana MJ, Sharkey EM, Eiseman JL, Creighton DJ. Hamilton DS, et al. Among authors: creighton dj. J Med Chem. 1999 May 20;42(10):1823-7. doi: 10.1021/jm980712o. J Med Chem. 1999. PMID: 10346934

9

Pharmacokinetics and antitumor properties in tumor-bearing mice of an enediol analogue inhibitor of glyoxalase I.

Sharkey EM, O'Neill HB, Kavarana MJ, Wang H, Creighton DJ, Sentz DL, Eiseman JL. Sharkey EM, et al. Among authors: creighton dj. Cancer Chemother Pharmacol. 2000;46(2):156-66. doi: 10.1007/s002800000130. Cancer Chemother Pharmacol. 2000. PMID: 10972486

10

Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I.

Kalsi A, Kavarana MJ, Lu T, Whalen DL, Hamilton DS, Creighton DJ. Kalsi A, et al. Among authors: creighton dj. J Med Chem. 2000 Oct 19;43(21):3981-6. doi: 10.1021/jm000160l. J Med Chem. 2000. PMID: 11052803

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