Hamilton DS - Search Results

1

Glyoxalase I inhibitors in cancer chemotherapy.

Creighton DJ, Zheng ZB, Holewinski R, Hamilton DS, Eiseman JL. Creighton DJ, et al. Among authors: hamilton ds. Biochem Soc Trans. 2003 Dec;31(Pt 6):1378-82. doi: 10.1042/bst0311378. Biochem Soc Trans. 2003. PMID: 14641067 Review.

2

Caution: the glycylmethyl and glycylethyl esters of glutathione are substrates for glyoxalase I.

Hamilton DS, Creighton DJ. Hamilton DS, et al. Biochim Biophys Acta. 1992 Sep 23;1159(2):203-8. doi: 10.1016/0167-4838(92)90026-a. Biochim Biophys Acta. 1992. PMID: 1390924

3

Inhibition of glyoxalase I by the enediol mimic S-(N-hydroxy-N-methylcarbamoyl)glutathione. The possible basis of a tumor-selective anticancer strategy.

Hamilton DS, Creighton DJ. Hamilton DS, et al. J Biol Chem. 1992 Dec 15;267(35):24933-6. J Biol Chem. 1992. PMID: 1459997 Free article.

4

S-(N-aryl-N-hydroxycarbamoyl)glutathione derivatives are tight-binding inhibitors of glyoxalase I and slow substrates for glyoxalase II.

Murthy NS, Bakeris T, Kavarana MJ, Hamilton DS, Lan Y, Creighton DJ. Murthy NS, et al. Among authors: hamilton ds. J Med Chem. 1994 Jul 8;37(14):2161-6. doi: 10.1021/jm00040a007. J Med Chem. 1994. PMID: 8035422

5

A new method for rapidly generating inhibitors of glyoxalase I inside tumor cells using S-(N-aryl-N-hydroxycarbamoyl)ethylsulfoxides.

Hamilton DS, Kavarana MJ, Sharkey EM, Eiseman JL, Creighton DJ. Hamilton DS, et al. J Med Chem. 1999 May 20;42(10):1823-7. doi: 10.1021/jm980712o. J Med Chem. 1999. PMID: 10346934

6

Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I.

Kalsi A, Kavarana MJ, Lu T, Whalen DL, Hamilton DS, Creighton DJ. Kalsi A, et al. Among authors: hamilton ds. J Med Chem. 2000 Oct 19;43(21):3981-6. doi: 10.1021/jm000160l. J Med Chem. 2000. PMID: 11052803

7

Brief history of glyoxalase I and what we have learned about metal ion-dependent, enzyme-catalyzed isomerizations.

Creighton DJ, Hamilton DS. Creighton DJ, et al. Among authors: hamilton ds. Arch Biochem Biophys. 2001 Mar 1;387(1):1-10. doi: 10.1006/abbi.2000.2253. Arch Biochem Biophys. 2001. PMID: 11368170 Review.

8

Mechanism of the glutathione transferase-catalyzed conversion of antitumor 2-crotonyloxymethyl-2-cycloalkenones to GSH adducts.

Hamilton DS, Zhang X, Ding Z, Hubatsch I, Mannervik B, Houk KN, Ganem B, Creighton DJ. Hamilton DS, et al. J Am Chem Soc. 2003 Dec 10;125(49):15049-58. doi: 10.1021/ja030396p. J Am Chem Soc. 2003. PMID: 14653739

9

Reaction of COTC with glutathione: structure of the putative glyoxalase I inhibitor.

Huntley CF, Hamilton DS, Creighton DJ, Ganem B. Huntley CF, et al. Among authors: hamilton ds. Org Lett. 2000 Oct 5;2(20):3143-4. doi: 10.1021/ol006341z. Org Lett. 2000. PMID: 11009366

10

Glutathionyl transferase catalyzed addition of glutathione to COMC: a new hypothesis for antitumor activity.

Hamilton DS, Ding Z, Ganem B, Creighton DJ. Hamilton DS, et al. Org Lett. 2002 Apr 4;4(7):1209-12. doi: 10.1021/ol025650h. Org Lett. 2002. PMID: 11922820

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