Begley MJ - Search Results

1

Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome.

Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA. Begley MJ, et al. Mol Cell. 2003 Dec;12(6):1391-402. doi: 10.1016/s1097-2765(03)00486-6. Mol Cell. 2003. PMID: 14690594 Free article.

2

The structure and regulation of myotubularin phosphatases.

Begley MJ, Dixon JE. Begley MJ, et al. Curr Opin Struct Biol. 2005 Dec;15(6):614-20. doi: 10.1016/j.sbi.2005.10.016. Epub 2005 Nov 9. Curr Opin Struct Biol. 2005. PMID: 16289848 Review.

3

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.

Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE. Begley MJ, et al. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):927-32. doi: 10.1073/pnas.0510006103. Epub 2006 Jan 12. Proc Natl Acad Sci U S A. 2006. PMID: 16410353 Free PMC article.

4

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC. Begley MJ, et al. Nat Struct Mol Biol. 2015 Dec;22(12):983-90. doi: 10.1038/nsmb.3117. Epub 2015 Nov 9. Nat Struct Mol Biol. 2015. PMID: 26551075 Free PMC article.

5

Autoinhibition and isoform-specific dominant negative inhibition of the type II cGMP-dependent protein kinase.

Taylor MK, Ahmed R, Begley M, Uhler MD. Taylor MK, et al. J Biol Chem. 2002 Oct 4;277(40):37242-53. doi: 10.1074/jbc.M202060200. Epub 2002 Jul 1. J Biol Chem. 2002. PMID: 12093798 Free article.

6

Crystal structure of an inactive Akt2 kinase domain.

Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. Huang X, et al. Structure. 2003 Jan;11(1):21-30. doi: 10.1016/s0969-2126(02)00937-1. Structure. 2003. PMID: 12517337 Free article.

7

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus.

Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Liu P, et al. Nature. 2014 Apr 24;508(7497):541-5. doi: 10.1038/nature13079. Epub 2014 Mar 9. Nature. 2014. PMID: 24670654 Free PMC article.

8

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.

You MH, Kim BM, Chen CH, Begley MJ, Cantley LC, Lee TH. You MH, et al. Among authors: begley mj. Cell Death Differ. 2017 Feb;24(2):238-250. doi: 10.1038/cdd.2016.114. Epub 2016 Nov 4. Cell Death Differ. 2017. PMID: 28141794 Free PMC article.

9

A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2.

Breitkopf SB, Yang X, Begley MJ, Kulkarni M, Chiu YH, Turke AB, Lauriol J, Yuan M, Qi J, Engelman JA, Hong P, Kontaridis MI, Cantley LC, Perrimon N, Asara JM. Breitkopf SB, et al. Among authors: begley mj. Sci Rep. 2016 Feb 3;6:20471. doi: 10.1038/srep20471. Sci Rep. 2016. PMID: 26839216 Free PMC article.

10

Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling.

Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, Tomaselli GF, Rosenzweig A. Das S, et al. Among authors: begley mj. Circulation. 2012 Oct 30;126(18):2208-19. doi: 10.1161/CIRCULATIONAHA.112.115592. Epub 2012 Sep 26. Circulation. 2012. PMID: 23019294 Free PMC article.

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