Toker L - Search Results

1

Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.

Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS. Aharoni A, et al. Among authors: toker l. Proc Natl Acad Sci U S A. 2004 Jan 13;101(2):482-7. doi: 10.1073/pnas.2536901100. Epub 2003 Dec 26. Proc Natl Acad Sci U S A. 2004. PMID: 14695884 Free PMC article.

2

Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.

Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Harel M, et al. Among authors: toker l. Nat Struct Mol Biol. 2004 May;11(5):412-9. doi: 10.1038/nsmb767. Epub 2004 Apr 18. Nat Struct Mol Biol. 2004. PMID: 15098021

3

Directed evolution of serum paraoxonase PON3 by family shuffling and ancestor/consensus mutagenesis, and its biochemical characterization.

Khersonsky O, Rosenblat M, Toker L, Yacobson S, Hugenmatter A, Silman I, Sussman JL, Aviram M, Tawfik DS. Khersonsky O, et al. Among authors: toker l. Biochemistry. 2009 Jul 21;48(28):6644-54. doi: 10.1021/bi900583y. Biochemistry. 2009. PMID: 19492856

4

3-D structure of serum paraoxonase 1 sheds light on its activity, stability, solubility and crystallizability.

Harel M, Brumshtein B, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL. Harel M, et al. Among authors: toker l. Arh Hig Rada Toksikol. 2007 Sep;58(3):347-53. doi: 10.2478/v10004-007-0028-0. Arh Hig Rada Toksikol. 2007. PMID: 17913690 Free article.

5

X-ray structure of human acid-beta-glucosidase, the defective enzyme in Gaucher disease.

Dvir H, Harel M, McCarthy AA, Toker L, Silman I, Futerman AH, Sussman JL. Dvir H, et al. Among authors: toker l. EMBO Rep. 2003 Jul;4(7):704-9. doi: 10.1038/sj.embor.embor873. EMBO Rep. 2003. PMID: 12792654 Free PMC article.

6

X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease.

Premkumar L, Sawkar AR, Boldin-Adamsky S, Toker L, Silman I, Kelly JW, Futerman AH, Sussman JL. Premkumar L, et al. Among authors: toker l. J Biol Chem. 2005 Jun 24;280(25):23815-9. doi: 10.1074/jbc.M502799200. Epub 2005 Apr 6. J Biol Chem. 2005. PMID: 15817452 Free article.

We recently determined the x-ray structure of GlcCerase to 2.0 A resolution (Dvir, H., Harel, M., McCarthy, A. A., Toker, L., Silman, I., Futerman, A. H., and Sussman, J. L. (2003) EMBO Rep.4, 704-709) and have now solved the structure of Glc-Cerase conjugate …

We recently determined the x-ray structure of GlcCerase to 2.0 A resolution (Dvir, H., Harel, M., McCarthy, A. A., Toker, L., …

7

Effect of heat shock on acetylcholinesterase activity in chick muscle cultures.

Eichler J, Toker L, Silman I. Eichler J, et al. Among authors: toker l. FEBS Lett. 1991 Nov 18;293(1-2):16-20. doi: 10.1016/0014-5793(91)81142-u. FEBS Lett. 1991. PMID: 1959652 Free article.

8

Acetylcholinesterase from Schistosoma mansoni: interaction of globular species with heparin.

Tarrab-Hazdai R, Toker L, Silman I, Arnon R. Tarrab-Hazdai R, et al. Among authors: toker l. Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):945-51. Biochem J. 1999. PMID: 10585885 Free PMC article.

9

Histochemical method for characterization of enzyme crystals: application to crystals of Torpedo californica acetylcholinesterase.

Nicolas A, Ferron F, Toker L, Sussman JL, Silman I. Nicolas A, et al. Among authors: toker l. Acta Crystallogr D Biol Crystallogr. 2001 Sep;57(Pt 9):1348-50. doi: 10.1107/s0907444901010411. Epub 2001 Aug 23. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11526341

10

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

Kryger G, Harel M, Giles K, Toker L, Velan B, Lazar A, Kronman C, Barak D, Ariel N, Shafferman A, Silman I, Sussman JL. Kryger G, et al. Among authors: toker l. Acta Crystallogr D Biol Crystallogr. 2000 Nov;56(Pt 11):1385-94. doi: 10.1107/s0907444900010659. Acta Crystallogr D Biol Crystallogr. 2000. PMID: 11053835

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