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Guselkumab in patients with moderately to severely active ulcerative colitis (QUASAR): phase 3 double-blind, randomised, placebo-controlled induction and maintenance studies.
Rubin DT, Allegretti JR, Panés J, Shipitofsky N, Yarandi SS, Huang KG, Germinaro M, Wilson R, Zhang H, Johanns J, Feagan BG, Hisamatsu T, Lichtenstein GR, Bressler B, Peyrin-Biroulet L, Sands BE, Dignass A; QUASAR Study Group. Rubin DT, et al. Lancet. 2025 Jan 4;405(10472):33-49. doi: 10.1016/S0140-6736(24)01927-5. Epub 2024 Dec 17. Lancet. 2025. PMID: 39706209 Clinical Trial.
p53 terminates the regenerative fetal-like state after colitis-associated injury.
Hartl K, Bayram Ş, Wetzel A, Harnack C, Lin M, Fischer AS, Liu L, Beccaceci G, Mastrobuoni G, Geisberger S, Forbes M, Monteiro BJE, Macino M, Flores RE, Engelmann C, Mollenkopf HJ, Schupp M, Tacke F, Sanders AD, Kempa S, Berger H, Sigal M. Hartl K, et al. Among authors: sigal m. Sci Adv. 2024 Oct 25;10(43):eadp8783. doi: 10.1126/sciadv.adp8783. Epub 2024 Oct 25. Sci Adv. 2024. PMID: 39453996 Free PMC article.
Optimization of diastereomeric dihydropyridines as antimalarials.
Van Horn KS, Zhao Y, Parvatkar PT, Maier J, Mutka T, Lacrue A, Brockmeier F, Ebert D, Wu W, Casandra DR, Namelikonda N, Yacoub J, Sigal M, Knapp S, Floyd D, Waterson D, Burrows JN, Duffy J, DeRisi JL, Kyle DE, Guy RK, Manetsch R. Van Horn KS, et al. Among authors: sigal m. Eur J Med Chem. 2024 Sep 5;275:116599. doi: 10.1016/j.ejmech.2024.116599. Epub 2024 Jun 18. Eur J Med Chem. 2024. PMID: 38909569
Intestinal retinol saturase is implicated in the development of obesity and epithelial homeostasis upon injury.
Kiefer MF, Meng Y, Yang N, Vahrenbrink M, Wulff S, Li C, Wowro SJ, Petricek KM, Sommerfeld M, Flores RE, Obermayer B, Piepelow K, Klaus S, Hartl K, Guillot A, Tacke F, Sigal M, Schupp M. Kiefer MF, et al. Among authors: sigal m. Am J Physiol Endocrinol Metab. 2024 Aug 1;327(2):E203-E216. doi: 10.1152/ajpendo.00035.2024. Epub 2024 Jun 19. Am J Physiol Endocrinol Metab. 2024. PMID: 38895981
Update S2k-Guideline Helicobacter pylori and gastroduodenal ulcer disease of the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS).
Fischbach W, Bornschein J, Hoffmann JC, Koletzko S, Link A, Macke L, Malfertheiner P, Schütte K, Selgrad DM, Suerbaum S, Schulz C; Collaborators. Fischbach W, et al. Z Gastroenterol. 2024 Feb;62(2):261-321. doi: 10.1055/a-2181-2225. Epub 2024 Feb 16. Z Gastroenterol. 2024. PMID: 38364851 Free article. No abstract available.
Training Health Center Staff in the Provision of Culturally Responsive Care for Sexual and Gender Minority Patients: Results of a Randomized Controlled Trial.
Mayer KH, Peretti M, McBurnie MA, King D, Smith NX, Crawford P, Loo S, Sigal M, Gillespie S, Davis JA, Cahill S, Grasso C, Keuroghlian AS. Mayer KH, et al. Among authors: sigal m. LGBT Health. 2024 Feb-Mar;11(2):131-142. doi: 10.1089/lgbt.2022.0322. Epub 2023 Dec 5. LGBT Health. 2024. PMID: 38052073 Clinical Trial.
325 results