Anderson AC - Search Results

1

The crystal structure of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveals a novel architecture for the bifunctional enzyme.

O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC. O'Neil RH, et al. Among authors: anderson ac. J Eukaryot Microbiol. 2003;50 Suppl:555-6. doi: 10.1111/j.1550-7408.2003.tb00627.x. J Eukaryot Microbiol. 2003. PMID: 14736160 No abstract available.

2

Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase.

O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC. O'Neil RH, et al. Among authors: anderson ac. J Biol Chem. 2003 Dec 26;278(52):52980-7. doi: 10.1074/jbc.M310328200. Epub 2003 Oct 9. J Biol Chem. 2003. PMID: 14555647 Free article.

3

A subgroup algorithm to identify cross-rotation peaks consistent with non-crystallographic symmetry.

Lilien RH, Bailey-Kellogg C, Anderson AC, Donald BR. Lilien RH, et al. Among authors: anderson ac. Acta Crystallogr D Biol Crystallogr. 2004 Jun;60(Pt 6):1057-67. doi: 10.1107/S090744490400695X. Epub 2004 May 21. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 15159565

4

Toxoplasma gondii: generation of novel truncation mutations in the linker domain of dihydrofolate reductase-thymidylate synthase.

Belperron AA, Fox BA, O'Neil RH, Peaslee KA, Horii T, Anderson AC, Bzik DJ. Belperron AA, et al. Among authors: anderson ac. Exp Parasitol. 2004 Mar-Apr;106(3-4):179-82. doi: 10.1016/j.exppara.2004.03.002. Exp Parasitol. 2004. PMID: 15172226 No abstract available.

5

A novel ensemble-based scoring and search algorithm for protein redesign and its application to modify the substrate specificity of the gramicidin synthetase a phenylalanine adenylation enzyme.

Lilien RH, Stevens BW, Anderson AC, Donald BR. Lilien RH, et al. Among authors: anderson ac. J Comput Biol. 2005 Jul-Aug;12(6):740-61. doi: 10.1089/cmb.2005.12.740. J Comput Biol. 2005. PMID: 16108714

6

Redesigning the PheA domain of gramicidin synthetase leads to a new understanding of the enzyme's mechanism and selectivity.

Stevens BW, Lilien RH, Georgiev I, Donald BR, Anderson AC. Stevens BW, et al. Among authors: anderson ac. Biochemistry. 2006 Dec 26;45(51):15495-504. doi: 10.1021/bi061788m. Epub 2006 Dec 19. Biochemistry. 2006. PMID: 17176071

7

The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition.

Finer-Moore JS, Anderson AC, O'Neil RH, Costi MP, Ferrari S, Krucinski J, Stroud RM. Finer-Moore JS, et al. Among authors: anderson ac. Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1320-34. doi: 10.1107/S0907444905022638. Epub 2005 Sep 28. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 16204883

8

Predicting resistance mutations using protein design algorithms.

Frey KM, Georgiev I, Donald BR, Anderson AC. Frey KM, et al. Among authors: anderson ac. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13707-12. doi: 10.1073/pnas.1002162107. Epub 2010 Jul 19. Proc Natl Acad Sci U S A. 2010. PMID: 20643959 Free PMC article.

9

Computational structure-based redesign of enzyme activity.

Chen CY, Georgiev I, Anderson AC, Donald BR. Chen CY, et al. Among authors: anderson ac. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3764-9. doi: 10.1073/pnas.0900266106. Epub 2009 Feb 19. Proc Natl Acad Sci U S A. 2009. PMID: 19228942 Free PMC article.

10

Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein-ligand interactions including a structural basis for observed antifolate resistance.

Anderson AC. Anderson AC. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Mar 1;61(Pt 3):258-62. doi: 10.1107/S1744309105002435. Epub 2005 Feb 8. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005. PMID: 16511011 Free PMC article.

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