Miners JO - Search Results

1

Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

Miners JO, Smith PA, Sorich MJ, McKinnon RA, Mackenzie PI. Miners JO, et al. Annu Rev Pharmacol Toxicol. 2004;44:1-25. doi: 10.1146/annurev.pharmtox.44.101802.121546. Annu Rev Pharmacol Toxicol. 2004. PMID: 14744236 Review.

2

Rapid prediction of chemical metabolism by human UDP-glucuronosyltransferase isoforms using quantum chemical descriptors derived with the electronegativity equalization method.

Sorich MJ, McKinnon RA, Miners JO, Winkler DA, Smith PA. Sorich MJ, et al. Among authors: miners jo. J Med Chem. 2004 Oct 7;47(21):5311-7. doi: 10.1021/jm0495529. J Med Chem. 2004. PMID: 15456275

3

S-Naproxen and desmethylnaproxen glucuronidation by human liver microsomes and recombinant human UDP-glucuronosyltransferases (UGT): role of UGT2B7 in the elimination of naproxen.

Bowalgaha K, Elliot DJ, Mackenzie PI, Knights KM, Swedmark S, Miners JO. Bowalgaha K, et al. Among authors: miners jo. Br J Clin Pharmacol. 2005 Oct;60(4):423-33. doi: 10.1111/j.1365-2125.2005.02446.x. Br J Clin Pharmacol. 2005. PMID: 16187975 Free PMC article.

4

In vitro-in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises.

Miners JO, Knights KM, Houston JB, Mackenzie PI. Miners JO, et al. Biochem Pharmacol. 2006 May 28;71(11):1531-9. doi: 10.1016/j.bcp.2005.12.019. Epub 2006 Feb 7. Biochem Pharmacol. 2006. PMID: 16455060 Review.

5

Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation.

Uchaipichat V, Winner LK, Mackenzie PI, Elliot DJ, Williams JA, Miners JO. Uchaipichat V, et al. Among authors: miners jo. Br J Clin Pharmacol. 2006 Apr;61(4):427-39. doi: 10.1111/j.1365-2125.2006.02588.x. Br J Clin Pharmacol. 2006. PMID: 16542204 Free PMC article.

6

In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction.

Rowland A, Elliot DJ, Williams JA, Mackenzie PI, Dickinson RG, Miners JO. Rowland A, et al. Among authors: miners jo. Drug Metab Dispos. 2006 Jun;34(6):1055-62. doi: 10.1124/dmd.106.009340. Epub 2006 Mar 24. Drug Metab Dispos. 2006. PMID: 16565174

7

Sulfinpyrazone C-glucuronidation is catalyzed selectively by human UDP-glucuronosyltransferase 1A9.

Kerdpin O, Elliot DJ, Mackenzie PI, Miners JO. Kerdpin O, et al. Among authors: miners jo. Drug Metab Dispos. 2006 Dec;34(12):1950-3. doi: 10.1124/dmd.106.012385. Epub 2006 Sep 19. Drug Metab Dispos. 2006. PMID: 16985098

8

The importance of local chemical structure for chemical metabolism by human uridine 5'-diphosphate-glucuronosyltransferase.

Sorich MJ, McKinnon RA, Miners JO, Smith PA. Sorich MJ, et al. Among authors: miners jo. J Chem Inf Model. 2006 Nov-Dec;46(6):2692-7. doi: 10.1021/ci600248e. J Chem Inf Model. 2006. PMID: 17125209

9

Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates.

Sorich MJ, Smith PA, Miners JO, Mackenzie PI, McKinnon RA. Sorich MJ, et al. Among authors: miners jo. Curr Drug Metab. 2008 Jan;9(1):60-9. doi: 10.2174/138920008783331167. Curr Drug Metab. 2008. PMID: 18220572 Review.

10

The "albumin effect" and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities.

Rowland A, Knights KM, Mackenzie PI, Miners JO. Rowland A, et al. Among authors: miners jo. Drug Metab Dispos. 2008 Jun;36(6):1056-62. doi: 10.1124/dmd.108.021105. Epub 2008 Mar 24. Drug Metab Dispos. 2008. PMID: 18362158

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