Smith PA - Search Results

1

Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

Miners JO, Smith PA, Sorich MJ, McKinnon RA, Mackenzie PI. Miners JO, et al. Among authors: smith pa. Annu Rev Pharmacol Toxicol. 2004;44:1-25. doi: 10.1146/annurev.pharmtox.44.101802.121546. Annu Rev Pharmacol Toxicol. 2004. PMID: 14744236 Review.

2

Glucuronidation of bioflavonoids by human UGT1A10: structure-function relationships.

Lewinsky RH, Smith PA, Mackenzie PI. Lewinsky RH, et al. Among authors: smith pa. Xenobiotica. 2005 Feb;35(2):117-29. doi: 10.1080/00498250400028189. Xenobiotica. 2005. PMID: 16019943

3

In silico insights: chemical and structural characteristics associated with uridine diphosphate-glucuronosyltransferase substrate selectivity.

Smith PA, Sorich MJ, McKinnon RA, Miners JO. Smith PA, et al. Clin Exp Pharmacol Physiol. 2003 Nov;30(11):836-40. doi: 10.1046/j.1440-1681.2003.03923.x. Clin Exp Pharmacol Physiol. 2003. PMID: 14678246

4

Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases.

Smith PA, Sorich MJ, Low LS, McKinnon RA, Miners JO. Smith PA, et al. J Mol Graph Model. 2004 Jul;22(6):507-17. doi: 10.1016/j.jmgm.2004.03.011. J Mol Graph Model. 2004. PMID: 15182810 Review.

5

Pharmacophore and quantitative structure-activity relationship modeling: complementary approaches for the rationalization and prediction of UDP-glucuronosyltransferase 1A4 substrate selectivity.

Smith PA, Sorich MJ, McKinnon RA, Miners JO. Smith PA, et al. J Med Chem. 2003 Apr 24;46(9):1617-26. doi: 10.1021/jm020397c. J Med Chem. 2003. PMID: 12699380

6

Comparison of linear and nonlinear classification algorithms for the prediction of drug and chemical metabolism by human UDP-glucuronosyltransferase isoforms.

Sorich MJ, Miners JO, McKinnon RA, Winkler DA, Burden FR, Smith PA. Sorich MJ, et al. Among authors: smith pa. J Chem Inf Comput Sci. 2003 Nov-Dec;43(6):2019-24. doi: 10.1021/ci034108k. J Chem Inf Comput Sci. 2003. PMID: 14632453

7

Multiple pharmacophores for the investigation of human UDP-glucuronosyltransferase isoform substrate selectivity.

Sorich MJ, Miners JO, McKinnon RA, Smith PA. Sorich MJ, et al. Among authors: smith pa. Mol Pharmacol. 2004 Feb;65(2):301-8. doi: 10.1124/mol.65.2.301. Mol Pharmacol. 2004. PMID: 14742671

8

Rapid prediction of chemical metabolism by human UDP-glucuronosyltransferase isoforms using quantum chemical descriptors derived with the electronegativity equalization method.

Sorich MJ, McKinnon RA, Miners JO, Winkler DA, Smith PA. Sorich MJ, et al. Among authors: smith pa. J Med Chem. 2004 Oct 7;47(21):5311-7. doi: 10.1021/jm0495529. J Med Chem. 2004. PMID: 15456275

9

The importance of local chemical structure for chemical metabolism by human uridine 5'-diphosphate-glucuronosyltransferase.

Sorich MJ, McKinnon RA, Miners JO, Smith PA. Sorich MJ, et al. Among authors: smith pa. J Chem Inf Model. 2006 Nov-Dec;46(6):2692-7. doi: 10.1021/ci600248e. J Chem Inf Model. 2006. PMID: 17125209

10

Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates.

Sorich MJ, Smith PA, Miners JO, Mackenzie PI, McKinnon RA. Sorich MJ, et al. Among authors: smith pa. Curr Drug Metab. 2008 Jan;9(1):60-9. doi: 10.2174/138920008783331167. Curr Drug Metab. 2008. PMID: 18220572 Review.

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