Arrestin serves as a molecular switch, linking endogenous alpha2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation.
Wang Q, Lu R, Zhao J, Limbird LE.
Wang Q, et al.
J Biol Chem. 2006 Sep 8;281(36):25948-55. doi: 10.1074/jbc.M605415200. Epub 2006 Jun 29.
J Biol Chem. 2006.
PMID: 16809338
Free article.
Our previous studies have demonstrated that neither receptor endocytosis nor arrestin is required for ERK activation by the alpha2-adrenergic receptor (Wang, Q., Zhao, J., Brady, A. E., Feng, J., Allen, P. B., Lefkowitz, R. J., Greengard, P., and Limbird, L. ...
Our previous studies have demonstrated that neither receptor endocytosis nor arrestin is required for ERK activation by the alpha2-adrenergi …