The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase.
Pluquet O, North S, Bhoumik A, Dimas K, Ronai Z, Hainaut P.
Pluquet O, et al.
J Biol Chem. 2003 Apr 4;278(14):11879-87. doi: 10.1074/jbc.M207396200. Epub 2003 Jan 16.
J Biol Chem. 2003.
PMID: 12531896
Free article.
In a previous study (North, S., El-Ghissassi, F., Pluquet, O., Verhaegh, G., and Hainaut, P. (2000) Oncogene 19, 1206-1214), we have shown that WR1065 activates wild-type p53 in cultured cells. ...
In a previous study (North, S., El-Ghissassi, F., Pluquet, O., Verhaegh, G., and Hainaut, P. (2000) Oncogene 19, 1206-1214), w …