Manning PT - Search Results

1

5-Fluorinated L-lysine analogues as selective induced nitric oxide synthase inhibitors.

Hallinan EA, Hagen TJ, Bergmanis A, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. Hallinan EA, et al. Among authors: manning pt. J Med Chem. 2004 Feb 12;47(4):900-6. doi: 10.1021/jm030348f. J Med Chem. 2004. PMID: 14761191

2

Synthesis and biological characterization of L-N(6)-(1-iminoethyl)lysine 5-tetrazole-amide, a prodrug of a selective iNOS inhibitor.

Hallinan EA, Tsymbalov S, Dorn CR, Pitzele BS, Hansen DW Jr, Moore WM, Jerome GM, Connor JR, Branson LF, Widomski DL, Zhang Y, Currie MG, Manning PT. Hallinan EA, et al. Among authors: manning pt. J Med Chem. 2002 Apr 11;45(8):1686-9. doi: 10.1021/jm010420e. J Med Chem. 2002. PMID: 11931623

3

3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: a potent and highly selective inducible nitric oxide synthase inhibitor.

Tsymbalov S, Hagen TJ, Moore WM, Jerome GM, Connor JR, Manning PT, Pitzele BS, Hallinan EA. Tsymbalov S, et al. Among authors: manning pt. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3337-9. doi: 10.1016/s0960-894x(02)00686-8. Bioorg Med Chem Lett. 2002. PMID: 12392746

4

4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain.

Hallinan EA, Kramer SW, Houdek SC, Moore WM, Jerome GM, Spangler DP, Stevens AM, Shieh HS, Manning PT, Pitzele BS. Hallinan EA, et al. Among authors: manning pt. Org Biomol Chem. 2003 Oct 21;1(20):3527-34. doi: 10.1039/b307563j. Org Biomol Chem. 2003. PMID: 14599013

5

Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase.

Moormann AE, Metz S, Toth MV, Moore WM, Jerome G, Kornmeier C, Manning P, Hansen DW Jr, Pitzele BS, Webber RK. Moormann AE, et al. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2651-3. doi: 10.1016/s0960-894x(01)00523-6. Bioorg Med Chem Lett. 2001. PMID: 11551770

6

Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase.

Connor JR, Manning PT, Settle SL, Moore WM, Jerome GM, Webber RK, Tjoeng FS, Currie MG. Connor JR, et al. Among authors: manning pt. Eur J Pharmacol. 1995 Jan 24;273(1-2):15-24. doi: 10.1016/0014-2999(94)00672-t. Eur J Pharmacol. 1995. PMID: 7537678

7

2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms.

Moore WM, Webber RK, Fok KF, Jerome GM, Connor JR, Manning PT, Wyatt PS, Misko TP, Tjoeng FS, Currie MG. Moore WM, et al. Among authors: manning pt. J Med Chem. 1996 Feb 2;39(3):669-72. doi: 10.1021/jm950766n. J Med Chem. 1996. PMID: 8576908

8

Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Webber RK, Metz S, Moore WM, Connor JR, Currie MG, Fok KF, Hagen TJ, Hansen DW Jr, Jerome GM, Manning PT, Pitzele BS, Toth MV, Trivedi M, Zupec ME, Tjoeng FS. Webber RK, et al. Among authors: manning pt. J Med Chem. 1998 Jan 1;41(1):96-101. doi: 10.1021/jm9705059. J Med Chem. 1998. PMID: 9438025

9

2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS).

Hansen DW Jr, Peterson KB, Trivedi M, Kramer SW, Webber RK, Tjoeng FS, Moore WM, Jerome GM, Kornmeier CM, Manning PT, Connor JR, Misko TP, Currie MG, Pitzele BS. Hansen DW Jr, et al. Among authors: manning pt. J Med Chem. 1998 Apr 23;41(9):1361-6. doi: 10.1021/jm9704715. J Med Chem. 1998. PMID: 9554868

10

2-Iminopyrrolidines as potent and selective inhibitors of human inducible nitric oxide synthase.

Hagen TJ, Bergmanis AA, Kramer SW, Fok KF, Schmelzer AE, Pitzele BS, Swenton L, Jerome GM, Kornmeier CM, Moore WM, Branson LF, Connor JR, Manning PT, Currie MG, Hallinan EA. Hagen TJ, et al. Among authors: manning pt. J Med Chem. 1998 Sep 10;41(19):3675-83. doi: 10.1021/jm970840x. J Med Chem. 1998. PMID: 9733492

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