Dinkova-Kostova AT - Search Results

1

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, Kensler TW, Talalay P. Wakabayashi N, et al. Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2040-5. doi: 10.1073/pnas.0307301101. Epub 2004 Feb 5. Proc Natl Acad Sci U S A. 2004. PMID: 14764894 Free PMC article.

2

Chemoprotective properties of phenylpropenoids, bis(benzylidene)cycloalkanones, and related Michael reaction acceptors: correlation of potencies as phase 2 enzyme inducers and radical scavengers.

Dinkova-Kostova AT, Abeygunawardana C, Talalay P. Dinkova-Kostova AT, et al. J Med Chem. 1998 Dec 17;41(26):5287-96. doi: 10.1021/jm980424s. J Med Chem. 1998. PMID: 9857096

3

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes.

Dinkova-Kostova AT, Talalay P. Dinkova-Kostova AT, et al. Carcinogenesis. 1999 May;20(5):911-4. doi: 10.1093/carcin/20.5.911. Carcinogenesis. 1999. PMID: 10334211

4

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.

Dinkova-Kostova AT, Talalay P. Dinkova-Kostova AT, et al. Free Radic Biol Med. 2000 Aug;29(3-4):231-40. doi: 10.1016/s0891-5849(00)00300-2. Free Radic Biol Med. 2000. PMID: 11035251 Free article. Review.

5

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups.

Dinkova-Kostova AT, Massiah MA, Bozak RE, Hicks RJ, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3404-9. doi: 10.1073/pnas.051632198. Proc Natl Acad Sci U S A. 2001. PMID: 11248091 Free PMC article.

6

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans.

Ye L, Dinkova-Kostova AT, Wade KL, Zhang Y, Shapiro TA, Talalay P. Ye L, et al. Clin Chim Acta. 2002 Feb;316(1-2):43-53. doi: 10.1016/s0009-8981(01)00727-6. Clin Chim Acta. 2002. PMID: 11750273

7

Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane.

Gao X, Dinkova-Kostova AT, Talalay P. Gao X, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15221-6. doi: 10.1073/pnas.261572998. Proc Natl Acad Sci U S A. 2001. PMID: 11752465 Free PMC article.

8

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.

Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, Yamamoto M, Talalay P. Dinkova-Kostova AT, et al. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11908-13. doi: 10.1073/pnas.172398899. Epub 2002 Aug 22. Proc Natl Acad Sci U S A. 2002. PMID: 12193649 Free PMC article.

9

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis.

Talalay P, Dinkova-Kostova AT, Holtzclaw WD. Talalay P, et al. Adv Enzyme Regul. 2003;43:121-34. doi: 10.1016/s0065-2571(02)00038-9. Adv Enzyme Regul. 2003. PMID: 12791387 Review. No abstract available.

10

The "Prochaska" microtiter plate bioassay for inducers of NQO1.

Fahey JW, Dinkova-Kostova AT, Stephenson KK, Talalay P. Fahey JW, et al. Methods Enzymol. 2004;382:243-58. doi: 10.1016/S0076-6879(04)82014-7. Methods Enzymol. 2004. PMID: 15047106 Review. No abstract available.

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