Pullen SM - Search Results

1

2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT.

Helsby NA, Ferry DM, Patterson AV, Pullen SM, Wilson WR. Helsby NA, et al. Among authors: pullen sm. Br J Cancer. 2004 Mar 8;90(5):1084-92. doi: 10.1038/sj.bjc.6601612. Br J Cancer. 2004. PMID: 14997211 Free PMC article.

2

Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures.

Wilson WR, Pullen SM, Hogg A, Helsby NA, Hicks KO, Denny WA. Wilson WR, et al. Among authors: pullen sm. Cancer Res. 2002 Mar 1;62(5):1425-32. Cancer Res. 2002. PMID: 11888915

3

Structure-activity relationships for 4-nitrobenzyl carbamates of 5-aminobenz[e]indoline minor groove alkylating agents as prodrugs for GDEPT in conjunction with E. coli nitroreductase.

Hay MP, Atwell GJ, Wilson WR, Pullen SM, Denny WA. Hay MP, et al. Among authors: pullen sm. J Med Chem. 2003 Jun 5;46(12):2456-66. doi: 10.1021/jm0205191. J Med Chem. 2003. PMID: 12773049

4

Aziridinyldinitrobenzamides: synthesis and structure-activity relationships for activation by E. coli nitroreductase.

Helsby NA, Atwell GJ, Yang S, Palmer BD, Anderson RF, Pullen SM, Ferry DM, Hogg A, Wilson WR, Denny WA. Helsby NA, et al. Among authors: pullen sm. J Med Chem. 2004 Jun 3;47(12):3295-307. doi: 10.1021/jm0498699. J Med Chem. 2004. PMID: 15163209

5

Synthesis and structure-activity relationships for 2,4-dinitrobenzamide-5-mustards as prodrugs for the Escherichia coli nfsB nitroreductase in gene therapy.

Atwell GJ, Yang S, Pruijn FB, Pullen SM, Hogg A, Patterson AV, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: pullen sm. J Med Chem. 2007 Mar 22;50(6):1197-212. doi: 10.1021/jm061062o. Epub 2007 Feb 28. J Med Chem. 2007. PMID: 17326614

6

Bystander effects of bioreductive drugs: potential for exploiting pathological tumor hypoxia with dinitrobenzamide mustards.

Wilson WR, Hicks KO, Pullen SM, Ferry DM, Helsby NA, Patterson AV. Wilson WR, et al. Among authors: pullen sm. Radiat Res. 2007 Jun;167(6):625-36. doi: 10.1667/RR0807.1. Radiat Res. 2007. PMID: 17523848

7

Mechanism of action and preclinical antitumor activity of the novel hypoxia-activated DNA cross-linking agent PR-104.

Patterson AV, Ferry DM, Edmunds SJ, Gu Y, Singleton RS, Patel K, Pullen SM, Hicks KO, Syddall SP, Atwell GJ, Yang S, Denny WA, Wilson WR. Patterson AV, et al. Among authors: pullen sm. Clin Cancer Res. 2007 Jul 1;13(13):3922-32. doi: 10.1158/1078-0432.CCR-07-0478. Clin Cancer Res. 2007. PMID: 17606726

8

DNA cross-links in human tumor cells exposed to the prodrug PR-104A: relationships to hypoxia, bioreductive metabolism, and cytotoxicity.

Singleton RS, Guise CP, Ferry DM, Pullen SM, Dorie MJ, Brown JM, Patterson AV, Wilson WR. Singleton RS, et al. Among authors: pullen sm. Cancer Res. 2009 May 1;69(9):3884-91. doi: 10.1158/0008-5472.CAN-08-4023. Epub 2009 Apr 14. Cancer Res. 2009. PMID: 19366798

9

Pre-clinical activity of PR-104 as monotherapy and in combination with sorafenib in hepatocellular carcinoma.

Abbattista MR, Jamieson SM, Gu Y, Nickel JE, Pullen SM, Patterson AV, Wilson WR, Guise CP. Abbattista MR, et al. Among authors: pullen sm. Cancer Biol Ther. 2015;16(4):610-22. doi: 10.1080/15384047.2015.1017171. Epub 2015 Apr 14. Cancer Biol Ther. 2015. PMID: 25869917 Free PMC article.

10

Synthesis and evaluation of 4-substituted analogues of 5-[N,N-bis (2-chloroethyl)amino]-2-nitrobenzamide as bioreductively activated prodrugs using an Escherichia coli nitroreductase.

Atwell GJ, Boyd M, Palmer BD, Anderson RF, Pullen SM, Wilson WR, Denny WA. Atwell GJ, et al. Among authors: pullen sm. Anticancer Drug Des. 1996 Oct;11(7):553-67. Anticancer Drug Des. 1996. PMID: 8921936

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