Edwards S - Search Results

1

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors with improved functional activity.

Zhang P, Bao L, Zuckett JF, Jia ZJ, Woolfrey J, Arfsten A, Edwards S, Sinha U, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY. Zhang P, et al. Among authors: edwards s. Bioorg Med Chem Lett. 2004 Feb 23;14(4):989-93. doi: 10.1016/j.bmcl.2003.11.080. Bioorg Med Chem Lett. 2004. PMID: 15013007

2

Design, synthesis, and structure-activity relationships of unsubstituted piperazinone-based transition state factor Xa inhibitors.

Huang W, Naughton MA, Yang H, Su T, Dam S, Wong PW, Arfsten A, Edwards S, Sinha U, Hollenbach S, Scarborough RM, Zhu BY. Huang W, et al. Among authors: edwards s. Bioorg Med Chem Lett. 2003 Feb 24;13(4):723-8. doi: 10.1016/s0960-894x(02)01037-5. Bioorg Med Chem Lett. 2003. PMID: 12639567

3

Design, synthesis, and SAR of anthranilamide-based factor Xa inhibitors incorporating substituted biphenyl P4 motifs.

Zhang P, Bao L, Zuckett JF, Goldman EA, Jia ZJ, Arfsten A, Edwards S, Sinha U, Hutchaleelaha A, Park G, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY. Zhang P, et al. Among authors: edwards s. Bioorg Med Chem Lett. 2004 Feb 23;14(4):983-7. doi: 10.1016/j.bmcl.2003.11.079. Bioorg Med Chem Lett. 2004. PMID: 15013006

4

Inhibition of purified factor Xa amidolytic activity may not be predictive of inhibition of in vivo thrombosis: implications for identification of therapeutically active inhibitors.

Sinha U, Lin PH, Edwards ST, Wong PW, Zhu B, Scarborough RM, Su T, Jia ZJ, Song Y, Zhang P, Clizbe L, Park G, Reed A, Hollenbach SJ, Malinowski J, Arfsten AE. Sinha U, et al. Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1098-104. doi: 10.1161/01.ATV.0000077248.22632.88. Epub 2003 May 15. Arterioscler Thromb Vasc Biol. 2003. PMID: 12750119

5

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 2: A survey of P4 motifs.

Jia ZJ, Wu Y, Huang W, Zhang P, Clizbe LA, Goldman EA, Sinha U, Arfsten AE, Edwards ST, Alphonso M, Hutchaleelaha A, Scarborough RM, Zhu BY. Jia ZJ, et al. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1221-7. doi: 10.1016/j.bmcl.2003.12.053. Bioorg Med Chem Lett. 2004. PMID: 14980670

6

1-(2-Naphthyl)-1H-pyrazole-5-carboxylamides as potent factor Xa inhibitors. Part 3: Design, synthesis and SAR of orally bioavailable benzamidine-P4 inhibitors.

Jia ZJ, Wu Y, Huang W, Zhang P, Song Y, Woolfrey J, Sinha U, Arfsten AE, Edwards ST, Hutchaleelaha A, Hollennbach SJ, Lambing JL, Scarborough RM, Zhu BY. Jia ZJ, et al. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1229-34. doi: 10.1016/j.bmcl.2003.12.054. Bioorg Med Chem Lett. 2004. PMID: 14980671

7

Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.

Zhang P, Huang W, Wang L, Bao L, Jia ZJ, Bauer SM, Goldman EA, Probst GD, Song Y, Su T, Fan J, Wu Y, Li W, Woolfrey J, Sinha U, Wong PW, Edwards ST, Arfsten AE, Clizbe LA, Kanter J, Pandey A, Park G, Hutchaleelaha A, Lambing JL, Hollenbach SJ, Scarborough RM, Zhu BY. Zhang P, et al. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2179-85. doi: 10.1016/j.bmcl.2009.02.111. Epub 2009 Mar 3. Bioorg Med Chem Lett. 2009. PMID: 19297154

8

Differences between human and rabbit coagulation factor X-implications for in vivo models of thrombosis.

Edwards ST, Betz A, James HL, Thompson E, Yonkovich SJ, Sinha U. Edwards ST, et al. Thromb Res. 2002 Apr 1;106(1):71-9. doi: 10.1016/s0049-3848(02)00076-2. Thromb Res. 2002. PMID: 12165292

9

Perspectives on vaccination among unvaccinated members of a Canadian indigenous population.

Shields T, King KD, Cripps S, Edwards SA, Kwong JC, Mecredy G, Chaurasia A, Douglas O, Cooke M. Shields T, et al. Among authors: edwards sa. Vaccine. 2025 Jan 9;47:126665. doi: 10.1016/j.vaccine.2024.126665. Online ahead of print. Vaccine. 2025. PMID: 39793536

10

Safety and cost of selective histopathological analysis for detecting cancer in surgical specimens: a systematic review.

Camilos AN, Bowley Schubert LC, Castro MP, Nann SD, Edwards S, Stretton B, Gupta AK, Kovoor JG, Marshall-Webb M, Maddern GJ. Camilos AN, et al. Among authors: edwards s. ANZ J Surg. 2025 Jan 6. doi: 10.1111/ans.19380. Online ahead of print. ANZ J Surg. 2025. PMID: 39760300 Review.

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