de Graaf M - Search Results

1

Pronounced antitumor efficacy by extracellular activation of a doxorubicin-glucuronide prodrug after adenoviral vector-mediated expression of a human antibody-enzyme fusion protein.

de Graaf M, Pinedo HM, Oosterhoff D, van der Meulen-Muileman IH, Gerritsen WR, Haisma HJ, Boven E. de Graaf M, et al. Hum Gene Ther. 2004 Mar;15(3):229-38. doi: 10.1089/104303404322886084. Hum Gene Ther. 2004. PMID: 15018732

2

Beta-glucuronidase-mediated drug release.

de Graaf M, Boven E, Scheeren HW, Haisma HJ, Pinedo HM. de Graaf M, et al. Curr Pharm Des. 2002;8(15):1391-403. doi: 10.2174/1381612023394485. Curr Pharm Des. 2002. PMID: 12052215 Review.

3

A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy.

de Graaf M, Nevalainen TJ, Scheeren HW, Pinedo HM, Haisma HJ, Boven E. de Graaf M, et al. Biochem Pharmacol. 2004 Dec 1;68(11):2273-81. doi: 10.1016/j.bcp.2004.08.004. Biochem Pharmacol. 2004. PMID: 15498517

4

A fully human anti-Ep-CAM scFv-beta-glucuronidase fusion protein for selective chemotherapy with a glucuronide prodrug.

de Graaf M, Boven E, Oosterhoff D, van der Meulen-Muileman IH, Huls GA, Gerritsen WR, Haisma HJ, Pinedo HM. de Graaf M, et al. Br J Cancer. 2002 Mar 4;86(5):811-8. doi: 10.1038/sj.bjc.6600143. Br J Cancer. 2002. PMID: 11875747 Free PMC article.

5

Secreted and tumour targeted human carboxylesterase for activation of irinotecan.

Oosterhoff D, Pinedo HM, van der Meulen IH, de Graaf M, Sone T, Kruyt FA, van Beusechem VW, Haisma HJ, Gerritsen WR. Oosterhoff D, et al. Among authors: de graaf m. Br J Cancer. 2002 Sep 9;87(6):659-64. doi: 10.1038/sj.bjc.6600519. Br J Cancer. 2002. PMID: 12237777 Free PMC article.

6

Adenoviral vector-mediated expression of a gene encoding secreted, EpCAM-targeted carboxylesterase-2 sensitises colon cancer spheroids to CPT-11.

Oosterhoff D, Overmeer RM, de Graaf M, van der Meulen IH, Giaccone G, van Beusechem VW, Haisma HJ, Pinedo HM, Gerritsen WR. Oosterhoff D, et al. Among authors: de graaf m. Br J Cancer. 2005 Mar 14;92(5):882-7. doi: 10.1038/sj.bjc.6602362. Br J Cancer. 2005. PMID: 15756257 Free PMC article.

7

Expression of scFvs and scFv fusion proteins in eukaryotic cells.

de Graaf M, van der Meulen-Muileman IH, Pinedo HM, Haisma HJ. de Graaf M, et al. Methods Mol Biol. 2002;178:379-87. doi: 10.1385/1-59259-240-6:379. Methods Mol Biol. 2002. PMID: 11968507 Review. No abstract available.

8

Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin.

de Graaf M, Pinedo HM, Quadir R, Haisma HJ, Boven E. de Graaf M, et al. Biochem Pharmacol. 2003 Jun 1;65(11):1875-81. doi: 10.1016/s0006-2952(03)00183-7. Biochem Pharmacol. 2003. PMID: 12781339

9

Cloning and characterization of human liver cytosolic beta-glycosidase.

de Graaf M, van Veen IC, van der Meulen-Muileman IH, Gerritsen WR, Pinedo HM, Haisma HJ. de Graaf M, et al. Biochem J. 2001 Jun 15;356(Pt 3):907-10. doi: 10.1042/0264-6021:3560907. Biochem J. 2001. PMID: 11389701 Free PMC article.

10

Activation of cardiac and smooth muscle-specific genes in primary human cells after forced expression of human myocardin.

van Tuyn J, Knaän-Shanzer S, van de Watering MJ, de Graaf M, van der Laarse A, Schalij MJ, van der Wall EE, de Vries AA, Atsma DE. van Tuyn J, et al. Among authors: de vries aa, de graaf m. Cardiovasc Res. 2005 Aug 1;67(2):245-55. doi: 10.1016/j.cardiores.2005.04.013. Cardiovasc Res. 2005. PMID: 15907818

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