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Page 1
Design, synthesis, and biological activity of novel factor Xa inhibitors: 4-aryloxy substituents of 2,6-diphenoxypyridines.
Ng HP, Buckman BO, Eagen KA, Guilford WJ, Kochanny MJ, Mohan R, Shaw KJ, Wu SC, Lentz D, Liang A, Trinh L, Ho E, Smith D, Subramanyam B, Vergona R, Walters J, White KA, Sullivan ME, Morrissey MM, Phillips GB. Ng HP, et al. Among authors: subramanyam b. Bioorg Med Chem. 2002 Mar;10(3):657-66. doi: 10.1016/s0968-0896(01)00338-8. Bioorg Med Chem. 2002. PMID: 11814853
Design, synthesis, and activity of 2-imidazol-1-ylpyrimidine derived inducible nitric oxide synthase dimerization inhibitors.
Davey DD, Adler M, Arnaiz D, Eagen K, Erickson S, Guilford W, Kenrick M, Morrissey MM, Ohlmeyer M, Pan G, Paradkar VM, Parkinson J, Polokoff M, Saionz K, Santos C, Subramanyam B, Vergona R, Wei RG, Whitlow M, Ye B, Zhao ZS, Devlin JJ, Phillips G. Davey DD, et al. Among authors: subramanyam b. J Med Chem. 2007 Mar 22;50(6):1146-57. doi: 10.1021/jm061319i. Epub 2007 Feb 23. J Med Chem. 2007. PMID: 17315988
Discovery of N-[2-[5-[Amino(imino)methyl]-2-hydroxyphenoxy]-3, 5-difluoro-6-[3-(4, 5-dihydro-1-methyl-1H-imidazol-2-yl)phenoxy]pyridin-4-yl]-N-methylgl y cine (ZK-807834): a potent, selective, and orally active inhibitor of the blood coagulation enzyme factor Xa.
Phillips GB, Buckman BO, Davey DD, Eagen KA, Guilford WJ, Hinchman J, Ho E, Koovakkat S, Liang A, Light DR, Mohan R, Ng HP, Post JM, Shaw KJ, Smith D, Subramanyam B, Sullivan ME, Trinh L, Vergona R, Walters J, White K, Whitlow M, Wu S, Xu W, Morrissey MM. Phillips GB, et al. Among authors: subramanyam b. J Med Chem. 1998 Sep 10;41(19):3557-62. doi: 10.1021/jm980280h. J Med Chem. 1998. PMID: 9733480 No abstract available.
Reversible, orally available ADP receptor (P2Y12) antagonists Part I: Hit to lead process.
Islam I, Yuan S, Wei RG, Xu W, Morrissey M, Mohan R, Zheng D, DiMella A, Dunning L, Snider M, Subramanyam B, Tseng JL, Bryant JA, Buckman BO. Islam I, et al. Among authors: subramanyam b. Bioorg Med Chem Lett. 2018 May 15;28(9):1459-1463. doi: 10.1016/j.bmcl.2018.03.090. Epub 2018 Mar 31. Bioorg Med Chem Lett. 2018. PMID: 29628327
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1.
Liang M, Mallari C, Rosser M, Ng HP, May K, Monahan S, Bauman JG, Islam I, Ghannam A, Buckman B, Shaw K, Wei GP, Xu W, Zhao Z, Ho E, Shen J, Oanh H, Subramanyam B, Vergona R, Taub D, Dunning L, Harvey S, Snider RM, Hesselgesser J, Morrissey MM, Perez HD. Liang M, et al. Among authors: subramanyam b. J Biol Chem. 2000 Jun 23;275(25):19000-8. doi: 10.1074/jbc.M001222200. J Biol Chem. 2000. PMID: 10748002 Free article.
156 results