Shi ZD - Search Results

1

Macrocyclization in the design of non-phosphorus-containing Grb2 SH2 domain-binding ligands.

Shi ZD, Wei CQ, Lee K, Liu H, Zhang M, Araki T, Roberts LR, Worthy KM, Fisher RJ, Neel BG, Kelley JA, Yang D, Burke TR Jr. Shi ZD, et al. J Med Chem. 2004 Apr 8;47(8):2166-9. doi: 10.1021/jm030510e. J Med Chem. 2004. PMID: 15056012

2

A novel macrocyclic tetrapeptide mimetic that exhibits low-picomolar Grb2 SH2 domain-binding affinity.

Shi ZD, Lee K, Liu H, Zhang M, Roberts LR, Worthy KM, Fivash MJ, Fisher RJ, Yang D, Burke TR Jr. Shi ZD, et al. Biochem Biophys Res Commun. 2003 Oct 17;310(2):378-83. doi: 10.1016/j.bbrc.2003.09.029. Biochem Biophys Res Commun. 2003. PMID: 14521921

3

Synthesis of a 5-methylindolyl-containing macrocycle that displays ultrapotent Grb2 SH2 domain-binding affinity.

Shi ZD, Lee K, Wei CQ, Roberts LR, Worthy KM, Fisher RJ, Burke TR Jr. Shi ZD, et al. J Med Chem. 2004 Feb 12;47(4):788-91. doi: 10.1021/jm030440b. J Med Chem. 2004. PMID: 14761181

4

Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic.

Shi ZD, Karki RG, Oishi S, Worthy KM, Bindu LK, Dharmawardana PG, Nicklaus MC, Bottaro DP, Fisher RJ, Burke TR Jr. Shi ZD, et al. Bioorg Med Chem Lett. 2005 Mar 1;15(5):1385-8. doi: 10.1016/j.bmcl.2005.01.017. Bioorg Med Chem Lett. 2005. PMID: 15713392

5

Ring-closing metathesis of C-terminal allylglycine residues with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic as an approach to novel Grb2 SH2 domain-binding macrocycles.

Oishi S, Shi ZD, Worthy KM, Bindu LK, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: shi zd. Chembiochem. 2005 Apr;6(4):668-74. doi: 10.1002/cbic.200400298. Chembiochem. 2005. PMID: 15719347

6

Evaluation of macrocyclic Grb2 SH2 domain-binding peptide mimetics prepared by ring-closing metathesis of C-terminal allylglycines with an N-terminal beta-vinyl-substituted phosphotyrosyl mimetic.

Oishi S, Karki RG, Shi ZD, Worthy KM, Bindu L, Chertov O, Esposito D, Frank P, Gillette WK, Maderia M, Hartley J, Nicklaus MC, Barchi JJ Jr, Fisher RJ, Burke TR Jr. Oishi S, et al. Among authors: shi zd. Bioorg Med Chem. 2005 Apr 1;13(7):2431-8. doi: 10.1016/j.bmc.2005.01.052. Bioorg Med Chem. 2005. PMID: 15755645

7

Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity.

Shi ZD, Liu H, Zhang M, Worthy KM, Bindu L, Yang D, Fisher RJ, Burke TR Jr. Shi ZD, et al. Bioorg Med Chem. 2005 Jul 1;13(13):4200-8. doi: 10.1016/j.bmc.2005.04.028. Bioorg Med Chem. 2005. PMID: 15893931

8

Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform.

Kang SU, Shi ZD, Worthy KM, Bindu LK, Dharmawardana PG, Choyke SJ, Bottaro DP, Fisher RJ, Burke TR Jr. Kang SU, et al. Among authors: shi zd. J Med Chem. 2005 Jun 16;48(12):3945-8. doi: 10.1021/jm050059m. J Med Chem. 2005. PMID: 15943469

9

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain.

Phan J, Shi ZD, Burke TR Jr, Waugh DS. Phan J, et al. Among authors: shi zd. J Mol Biol. 2005 Oct 14;353(1):104-15. doi: 10.1016/j.jmb.2005.08.037. J Mol Biol. 2005. PMID: 16165154

10

Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.

Choi WJ, Shi ZD, Worthy KM, Bindu L, Karki RG, Nicklaus MC, Fisher RJ, Burke TR Jr. Choi WJ, et al. Among authors: shi zd. Bioorg Med Chem Lett. 2006 Oct 15;16(20):5265-9. doi: 10.1016/j.bmcl.2006.08.004. Bioorg Med Chem Lett. 2006. PMID: 16908148 Free PMC article.

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