Shen Y - Search Results

1

Structure of anthrax edema factor-calmodulin-adenosine 5'-(alpha,beta-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site.

Shen Y, Guo Q, Zhukovskaya NL, Drum CL, Bohm A, Tang WJ. Shen Y, et al. Biochem Biophys Res Commun. 2004 Apr 30;317(2):309-14. doi: 10.1016/j.bbrc.2004.03.046. Biochem Biophys Res Commun. 2004. PMID: 15063758

2

Selective inhibition of anthrax edema factor by adefovir, a drug for chronic hepatitis B virus infection.

Shen Y, Zhukovskaya NL, Zimmer MI, Soelaiman S, Bergson P, Wang CR, Gibbs CS, Tang WJ. Shen Y, et al. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3242-7. doi: 10.1073/pnas.0306552101. Epub 2004 Feb 20. Proc Natl Acad Sci U S A. 2004. PMID: 14978283 Free PMC article.

3

Structural and kinetic analyses of the interaction of anthrax adenylyl cyclase toxin with reaction products cAMP and pyrophosphate.

Guo Q, Shen Y, Zhukovskaya NL, Florián J, Tang WJ. Guo Q, et al. Among authors: shen y. J Biol Chem. 2004 Jul 9;279(28):29427-35. doi: 10.1074/jbc.M402689200. Epub 2004 May 6. J Biol Chem. 2004. PMID: 15131111 Free article.

4

Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.

Shen Y, Zhukovskaya NL, Guo Q, Florián J, Tang WJ. Shen Y, et al. EMBO J. 2005 Mar 9;24(5):929-41. doi: 10.1038/sj.emboj.7600574. Epub 2005 Feb 17. EMBO J. 2005. PMID: 15719022 Free PMC article.

5

Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.

Drum CL, Yan SZ, Bard J, Shen YQ, Lu D, Soelaiman S, Grabarek Z, Bohm A, Tang WJ. Drum CL, et al. Nature. 2002 Jan 24;415(6870):396-402. doi: 10.1038/415396a. Nature. 2002. PMID: 11807546

6

Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin.

Drum CL, Shen Y, Rice PA, Bohm A, Tang WJ. Drum CL, et al. Among authors: shen y. Acta Crystallogr D Biol Crystallogr. 2001 Dec;57(Pt 12):1881-4. doi: 10.1107/s0907444901014937. Epub 2001 Nov 21. Acta Crystallogr D Biol Crystallogr. 2001. PMID: 11717504

7

Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.

Shen Y, Lee YS, Soelaiman S, Bergson P, Lu D, Chen A, Beckingham K, Grabarek Z, Mrksich M, Tang WJ. Shen Y, et al. EMBO J. 2002 Dec 16;21(24):6721-32. doi: 10.1093/emboj/cdf681. EMBO J. 2002. PMID: 12485993 Free PMC article.

8

Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough.

Soelaiman S, Wei BQ, Bergson P, Lee YS, Shen Y, Mrksich M, Shoichet BK, Tang WJ. Soelaiman S, et al. Among authors: shen y. J Biol Chem. 2003 Jul 11;278(28):25990-7. doi: 10.1074/jbc.M301232200. Epub 2003 Apr 3. J Biol Chem. 2003. PMID: 12676933 Free article.

9

Structural basis for the interaction of Bordetella pertussis adenylyl cyclase toxin with calmodulin.

Guo Q, Shen Y, Lee YS, Gibbs CS, Mrksich M, Tang WJ. Guo Q, et al. Among authors: shen y. EMBO J. 2005 Sep 21;24(18):3190-201. doi: 10.1038/sj.emboj.7600800. Epub 2005 Sep 1. EMBO J. 2005. PMID: 16138079 Free PMC article.

10

Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism.

Shen Y, Joachimiak A, Rosner MR, Tang WJ. Shen Y, et al. Nature. 2006 Oct 19;443(7113):870-4. doi: 10.1038/nature05143. Epub 2006 Oct 11. Nature. 2006. PMID: 17051221 Free PMC article.

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