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The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Kimura R, Kamino K, Yamamoto M, Nuripa A, Kida T, Kazui H, Hashimoto R, Tanaka T, Kudo T, Yamagata H, Tabara Y, Miki T, Akatsu H, Kosaka K, Funakoshi E, Nishitomi K, Sakaguchi G, Kato A, Hattori H, Uema T, Takeda M. Kimura R, et al. Among authors: takeda m. Hum Mol Genet. 2007 Jan 1;16(1):15-23. doi: 10.1093/hmg/ddl437. Epub 2006 Nov 29. Hum Mol Genet. 2007. PMID: 17135279
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1.
Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M. Tagami S, et al. Among authors: takeda m. Mol Cell Biol. 2008 Jan;28(1):165-76. doi: 10.1128/MCB.00863-07. Epub 2007 Oct 29. Mol Cell Biol. 2008. PMID: 17967888 Free PMC article.
Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor.
Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, Takemoto H, Minagawa K, Katoh T, Willem M, Haass C, Morihara T, Tanaka T, Kudo T, Hasegawa H, Nishimura M, Sakaguchi G, Kato A, Takeda M. Itoh N, et al. Among authors: takeda m. Neurodegener Dis. 2009;6(5-6):230-9. doi: 10.1159/000236902. Epub 2009 Sep 9. Neurodegener Dis. 2009. PMID: 19738368
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system.
Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, Deguchi K, Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M. Yanagida K, et al. Among authors: takeda m. EMBO Mol Med. 2009 Jul;1(4):223-35. doi: 10.1002/emmm.200900026. EMBO Mol Med. 2009. PMID: 20049724 Free PMC article.
Involvement of puromycin-sensitive aminopeptidase in proteolysis of tau protein in cultured cells, and attenuated proteolysis of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) mutant tau.
Yanagi K, Tanaka T, Kato K, Sadik G, Morihara T, Kudo T, Takeda M. Yanagi K, et al. Among authors: takeda m. Psychogeriatrics. 2009 Dec;9(4):157-66. doi: 10.1111/j.1479-8301.2010.00307.x. Psychogeriatrics. 2009. PMID: 20377816 Free article.
4,095 results