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The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.
Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG. Orsini F, et al. J Biol Chem. 2004 Jun 11;279(24):25689-95. doi: 10.1074/jbc.M401844200. Epub 2004 Apr 12. J Biol Chem. 2004. PMID: 15078873 Free article.
Deletion of p66shc gene protects against age-related endothelial dysfunction.
Francia P, delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, Lüscher TF, Volpe M, Cosentino F. Francia P, et al. Circulation. 2004 Nov 2;110(18):2889-95. doi: 10.1161/01.CIR.0000147731.24444.4D. Epub 2004 Oct 25. Circulation. 2004. PMID: 15505103
p66ShcA modulates tissue response to hindlimb ischemia.
Zaccagnini G, Martelli F, Fasanaro P, Magenta A, Gaetano C, Di Carlo A, Biglioli P, Giorgio M, Martin-Padura I, Pelicci PG, Capogrossi MC. Zaccagnini G, et al. Circulation. 2004 Jun 15;109(23):2917-23. doi: 10.1161/01.CIR.0000129309.58874.0F. Epub 2004 Jun 1. Circulation. 2004. PMID: 15173034
Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.
Napoli C, Martin-Padura I, de Nigris F, Giorgio M, Mansueto G, Somma P, Condorelli M, Sica G, De Rosa G, Pelicci P. Napoli C, et al. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2112-6. doi: 10.1073/pnas.0336359100. Epub 2003 Feb 5. Proc Natl Acad Sci U S A. 2003. PMID: 12571362 Free PMC article.
53 results