O'Doherty RM - Search Results

1

Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation.

Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF. Perdomo G, et al. J Biol Chem. 2004 Jun 25;279(26):27177-86. doi: 10.1074/jbc.M403566200. Epub 2004 Apr 22. J Biol Chem. 2004. PMID: 15105415 Free article.

2

Fatty acid-induced insulin resistance in L6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B.

Sinha S, Perdomo G, Brown NF, O'Doherty RM. Sinha S, et al. J Biol Chem. 2004 Oct 1;279(40):41294-301. doi: 10.1074/jbc.M406514200. Epub 2004 Jul 12. J Biol Chem. 2004. PMID: 15252018 Free article.

3

Hepatocyte growth factor is a novel stimulator of glucose uptake and metabolism in skeletal muscle cells.

Perdomo G, Martinez-Brocca MA, Bhatt BA, Brown NF, O'Doherty RM, Garcia-Ocaña A. Perdomo G, et al. J Biol Chem. 2008 May 16;283(20):13700-6. doi: 10.1074/jbc.M707551200. Epub 2008 Mar 24. J Biol Chem. 2008. PMID: 18362143 Free PMC article.

4

A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels.

Stefanovic-Racic M, Perdomo G, Mantell BS, Sipula IJ, Brown NF, O'Doherty RM. Stefanovic-Racic M, et al. Am J Physiol Endocrinol Metab. 2008 May;294(5):E969-77. doi: 10.1152/ajpendo.00497.2007. Epub 2008 Mar 18. Am J Physiol Endocrinol Metab. 2008. PMID: 18349115 Free article.

5

In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin.

Commerford SR, Peng L, Dubé JJ, O'Doherty RM. Commerford SR, et al. Am J Physiol Regul Integr Comp Physiol. 2004 Jul;287(1):R218-27. doi: 10.1152/ajpregu.00377.2003. Epub 2004 Mar 4. Am J Physiol Regul Integr Comp Physiol. 2004. PMID: 15001432 Free article.

6

Impaired activation of phosphatidylinositol 3-kinase by leptin is a novel mechanism of hepatic leptin resistance in diet-induced obesity.

Huang W, Dedousis N, Bhatt BA, O'Doherty RM. Huang W, et al. J Biol Chem. 2004 May 21;279(21):21695-700. doi: 10.1074/jbc.M401546200. Epub 2004 Mar 1. J Biol Chem. 2004. PMID: 14993225 Free article.

7

Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle.

Radin MS, Sinha S, Bhatt BA, Dedousis N, O'Doherty RM. Radin MS, et al. Diabetologia. 2008 Feb;51(2):336-46. doi: 10.1007/s00125-007-0861-3. Epub 2007 Dec 1. Diabetologia. 2008. PMID: 18060381

8

Leptin, skeletal muscle lipids, and lipid-induced insulin resistance.

Dube JJ, Bhatt BA, Dedousis N, Bonen A, O'Doherty RM. Dube JJ, et al. Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R642-50. doi: 10.1152/ajpregu.00133.2007. Epub 2007 May 9. Am J Physiol Regul Integr Comp Physiol. 2007. PMID: 17491114 Free article.

9

The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA.

Thapa D, Wu K, Stoner MW, Xie B, Zhang M, Manning JR, Lu Z, Li JH, Chen Y, Gucek M, Playford MP, Mehta NN, Harmon D, O'Doherty RM, Jurczak MJ, Sack MN, Scott I. Thapa D, et al. Among authors: o doherty rm. J Biol Chem. 2018 Nov 16;293(46):17676-17684. doi: 10.1074/jbc.AC118.005462. Epub 2018 Oct 15. J Biol Chem. 2018. PMID: 30323061 Free PMC article.

10

Hepatic overexpression of steroid sulfatase ameliorates mouse models of obesity and type 2 diabetes through sex-specific mechanisms.

Jiang M, He J, Kucera H, Gaikwad NW, Zhang B, Xu M, O'Doherty RM, Selcer KW, Xie W. Jiang M, et al. J Biol Chem. 2014 Mar 21;289(12):8086-97. doi: 10.1074/jbc.M113.535914. Epub 2014 Feb 4. J Biol Chem. 2014. PMID: 24497646 Free PMC article.

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