Gentsch C - Search Results

1

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines.

Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. Cryan JF, et al. Among authors: gentsch c. J Pharmacol Exp Ther. 2004 Sep;310(3):952-63. doi: 10.1124/jpet.104.066753. Epub 2004 Apr 27. J Pharmacol Exp Ther. 2004. PMID: 15113848

2

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

Spooren WP, Vassout A, Neijt HC, Kuhn R, Gasparini F, Roux S, Porsolt RD, Gentsch C. Spooren WP, et al. Among authors: gentsch c. J Pharmacol Exp Ther. 2000 Dec;295(3):1267-75. J Pharmacol Exp Ther. 2000. PMID: 11082464

3

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608).

Spooren WP, Schoeffter P, Gasparini F, Kuhn R, Gentsch C. Spooren WP, et al. Among authors: gentsch c. Eur J Pharmacol. 2002 Jan 25;435(2-3):161-70. doi: 10.1016/s0014-2999(01)01562-x. Eur J Pharmacol. 2002. PMID: 11821022

4

The selective nicotinic acetylcholine receptor alpha7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain.

Feuerbach D, Lingenhoehl K, Olpe HR, Vassout A, Gentsch C, Chaperon F, Nozulak J, Enz A, Bilbe G, McAllister K, Hoyer D. Feuerbach D, et al. Among authors: gentsch c. Neuropharmacology. 2009 Jan;56(1):254-63. doi: 10.1016/j.neuropharm.2008.08.025. Epub 2008 Aug 28. Neuropharmacology. 2009. PMID: 18793655

5

Differences in pre- and post-synaptic sensitivity to apomorphine between saline and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57BL/6 mice as reflected in climbing activity.

Spooren WP, Vassout A, Waldmeier P, Gentsch C. Spooren WP, et al. Among authors: gentsch c. Eur J Pharmacol. 1998 Jul 17;353(1):1-4. doi: 10.1016/s0014-2999(98)00382-3. Eur J Pharmacol. 1998. PMID: 9721033

6

Phosphinic acid analogues of GABA. 1. New potent and selective GABAB agonists.

Froestl W, Mickel SJ, Hall RG, von Sprecher G, Strub D, Baumann PA, Brugger F, Gentsch C, Jaekel J, Olpe HR, et al. Froestl W, et al. Among authors: gentsch c. J Med Chem. 1995 Aug 18;38(17):3297-312. doi: 10.1021/jm00017a015. J Med Chem. 1995. PMID: 7650684

7

In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article.

Kuhn R, Pagano A, Stoehr N, Vranesic I, Flor PJ, Lingenhöhl K, Spooren W, Gentsch C, Vassout A, Pilc A, Gasparini F. Kuhn R, et al. Among authors: gentsch c. Amino Acids. 2002;23(1-3):207-11. doi: 10.1007/s00726-001-0130-6. Amino Acids. 2002. PMID: 12373539 Review.

8

The effect of a subchronic post-lesion treatment with (-)-deprenyl on the sensitivity of 6-OHDA-lesioned rats to apomorphine and d-amphetamine.

Spooren WP, Waldmeier P, Gentsch C. Spooren WP, et al. Among authors: gentsch c. J Neural Transm (Vienna). 1999;106(9-10):825-33. doi: 10.1007/s007020050203. J Neural Transm (Vienna). 1999. PMID: 10599865

9

TUNEL-positive cells in the substantia nigra of C57BL/6 mice after a single bolus of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Spooren WP, Gentsch C, Wiessner C. Spooren WP, et al. Among authors: gentsch c. Neuroscience. 1998 Jul;85(2):649-51; discussion 653. doi: 10.1016/s0306-4522(97)00640-4. Neuroscience. 1998. PMID: 9622260 No abstract available.

10

Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects.

Rupprecht R, Rammes G, Eser D, Baghai TC, Schüle C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K. Rupprecht R, et al. Among authors: gentsch c. Science. 2009 Jul 24;325(5939):490-3. doi: 10.1126/science.1175055. Epub 2009 Jun 18. Science. 2009. PMID: 19541954 Clinical Trial.

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