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5-substituted derivatives of 6-halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with low picomolar affinity for alpha4beta2 nicotinic acetylcholine receptor and wide range of lipophilicity: potential probes for imaging with positron emission tomography.
Zhang Y, Pavlova OA, Chefer SI, Hall AW, Kurian V, Brown LL, Kimes AS, Mukhin AG, Horti AG. Zhang Y, et al. Among authors: chefer si. J Med Chem. 2004 May 6;47(10):2453-65. doi: 10.1021/jm030432v. J Med Chem. 2004. PMID: 15115389
Pharmacological and toxicological evaluation of 2-fluoro-3-(2(S)-azetidinylmethoxy)pyridine (2-F-A-85380), a ligand for imaging cerebral nicotinic acetylcholine receptors with positron emission tomography.
Vaupel DB, Tella SR, Huso DL, Wagner VO 3rd, Mukhin AG, Chefer SI, Horti AG, London ED, Koren AO, Kimes AS. Vaupel DB, et al. Among authors: chefer si. J Pharmacol Exp Ther. 2005 Jan;312(1):355-65. doi: 10.1124/jpet.104.073999. Epub 2004 Aug 26. J Pharmacol Exp Ther. 2005. PMID: 15331657
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