Kinoshita T - Search Results

1

Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors.

Terasaka T, Okumura H, Tsuji K, Kato T, Nakanishi I, Kinoshita T, Kato Y, Kuno M, Seki N, Naoe Y, Inoue T, Tanaka K, Nakamura K. Terasaka T, et al. Among authors: kinoshita t. J Med Chem. 2004 May 20;47(11):2728-31. doi: 10.1021/jm0499559. J Med Chem. 2004. PMID: 15139750

2

True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor.

Kinoshita T, Nakanishi I, Sato A, Tada T. Kinoshita T, et al. Bioorg Med Chem Lett. 2003 Jan 6;13(1):21-4. doi: 10.1016/s0960-894x(02)00852-1. Bioorg Med Chem Lett. 2003. PMID: 12467609

3

Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside.

Kinoshita T, Nishio N, Nakanishi I, Sato A, Fujii T. Kinoshita T, et al. Acta Crystallogr D Biol Crystallogr. 2003 Feb;59(Pt 2):299-303. doi: 10.1107/s090744490202190x. Epub 2003 Jan 23. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 12554940

4

Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors.

Terasaka T, Nakanishi I, Nakamura K, Eikyu Y, Kinoshita T, Nishio N, Sato A, Kuno M, Seki N, Sakane K. Terasaka T, et al. Among authors: kinoshita t. Bioorg Med Chem Lett. 2003 Mar 24;13(6):1115-8. doi: 10.1016/s0960-894x(03)00026-x. Bioorg Med Chem Lett. 2003. PMID: 12643924

5

Improving quality and harvest period of protein crystals for structure-based drug design: effects of a gel and a magnetic field on bovine adenosine deaminase crystals.

Kinoshita T, Ataka M, Warizaya M, Neya M, Fujii T. Kinoshita T, et al. Acta Crystallogr D Biol Crystallogr. 2003 Jul;59(Pt 7):1333-5. doi: 10.1107/s0907444903008187. Epub 2003 Jun 27. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 12832803

6

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase.

Kinoshita T, Nakanishi I, Warizaya M, Iwashita A, Kido Y, Hattori K, Fujii T. Kinoshita T, et al. FEBS Lett. 2004 Jan 2;556(1-3):43-6. doi: 10.1016/s0014-5793(03)01362-0. FEBS Lett. 2004. PMID: 14706823 Free article.

7

A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization.

Terasaka T, Kinoshita T, Kuno M, Nakanishi I. Terasaka T, et al. Among authors: kinoshita t. J Am Chem Soc. 2004 Jan 14;126(1):34-5. doi: 10.1021/ja038606l. J Am Chem Soc. 2004. PMID: 14709046

8

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors.

Terasaka T, Kinoshita T, Kuno M, Seki N, Tanaka K, Nakanishi I. Terasaka T, et al. Among authors: kinoshita t. J Med Chem. 2004 Jul 15;47(15):3730-43. doi: 10.1021/jm0306374. J Med Chem. 2004. PMID: 15239652

9

Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

Hattori K, Kido Y, Yamamoto H, Ishida J, Kamijo K, Murano K, Ohkubo M, Kinoshita T, Iwashita A, Mihara K, Yamazaki S, Matsuoka N, Teramura Y, Miyake H. Hattori K, et al. Among authors: kinoshita t. J Med Chem. 2004 Aug 12;47(17):4151-4. doi: 10.1021/jm0499256. J Med Chem. 2004. PMID: 15293985

10

Solution stirring initiates nucleation and improves the quality of adenosine deaminase crystals.

Adachi H, Takano K, Niino A, Matsumura H, Kinoshita T, Warizaya M, Inoue T, Mori Y, Sasaki T. Adachi H, et al. Among authors: kinoshita t. Acta Crystallogr D Biol Crystallogr. 2005 Jun;61(Pt 6):759-62. doi: 10.1107/S0907444905013466. Epub 2005 May 26. Acta Crystallogr D Biol Crystallogr. 2005. PMID: 15930635

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