Hotta K - Search Results

1

Nonspecific medium effects versus specific group positioning in the antibody and albumin catalysis of the base-promoted ring-opening reactions of benzisoxazoles.

Hu Y, Houk KN, Kikuchi K, Hotta K, Hilvert D. Hu Y, et al. Among authors: hotta k. J Am Chem Soc. 2004 Jul 7;126(26):8197-205. doi: 10.1021/ja0490727. J Am Chem Soc. 2004. PMID: 15225061

2

Catalysis on the coastline: theozyme, molecular dynamics, and free energy perturbation analysis of antibody 21D8 catalysis of the decarboxylation of 5-nitro-3-carboxybenzisoxazole.

Ujaque G, Tantillo DJ, Hu Y, Houk KN, Hotta K, Hilvert D. Ujaque G, et al. Among authors: hotta k. J Comput Chem. 2003 Jan 15;24(1):98-110. doi: 10.1002/jcc.10151. J Comput Chem. 2003. PMID: 12483679

3

Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism.

Hotta K, Wilson IA, Hilvert D. Hotta K, et al. Biochemistry. 2002 Jan 22;41(3):772-9. doi: 10.1021/bi0158167. Biochemistry. 2002. PMID: 11790098

4

Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.

Sato M, Yagishita F, Mino T, Uchiyama N, Patel A, Chooi YH, Goda Y, Xu W, Noguchi H, Yamamoto T, Hotta K, Houk KN, Tang Y, Watanabe K. Sato M, et al. Among authors: hotta k. Chembiochem. 2015 Nov 2;16(16):2294-8. doi: 10.1002/cbic.201500386. Epub 2015 Oct 2. Chembiochem. 2015. PMID: 26360642 Free PMC article.

5

Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.

Hotta K, Chen X, Paton RS, Minami A, Li H, Swaminathan K, Mathews II, Watanabe K, Oikawa H, Houk KN, Kim CY. Hotta K, et al. Nature. 2012 Mar 4;483(7389):355-8. doi: 10.1038/nature10865. Nature. 2012. PMID: 22388816 Free PMC article.

6

Precursor-directed biosynthesis of epothilone in Escherichia coli.

Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. Boddy CN, et al. Among authors: hotta k. J Am Chem Soc. 2004 Jun 23;126(24):7436-7. doi: 10.1021/ja048108s. J Am Chem Soc. 2004. PMID: 15198579

7

Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase.

Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. Boddy CN, et al. Among authors: hotta k. J Am Chem Soc. 2003 Mar 26;125(12):3428-9. doi: 10.1021/ja0298646. J Am Chem Soc. 2003. PMID: 12643694

8

Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli.

Watanabe K, Hotta K, Praseuth AP, Koketsu K, Migita A, Boddy CN, Wang CC, Oguri H, Oikawa H. Watanabe K, et al. Among authors: hotta k. Nat Chem Biol. 2006 Aug;2(8):423-8. doi: 10.1038/nchembio803. Epub 2006 Jun 25. Nat Chem Biol. 2006. PMID: 16799553

9

Epoxide hydrolase-lasalocid a structure provides mechanistic insight into polyether natural product biosynthesis.

Wong FT, Hotta K, Chen X, Fang M, Watanabe K, Kim CY. Wong FT, et al. Among authors: hotta k. J Am Chem Soc. 2015 Jan 14;137(1):86-9. doi: 10.1021/ja511374k. Epub 2014 Dec 31. J Am Chem Soc. 2015. PMID: 25535803

10

Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product.

Watanabe K, Hotta K, Nakaya M, Praseuth AP, Wang CC, Inada D, Takahashi K, Fukushi E, Oguri H, Oikawa H. Watanabe K, et al. Among authors: hotta k. J Am Chem Soc. 2009 Jul 8;131(26):9347-53. doi: 10.1021/ja902261a. J Am Chem Soc. 2009. PMID: 19514719 Free PMC article.

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