Kirkpatrick L - Search Results

1

Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling.

Ihle NT, Williams R, Chow S, Chew W, Berggren MI, Paine-Murrieta G, Minion DJ, Halter RJ, Wipf P, Abraham R, Kirkpatrick L, Powis G. Ihle NT, et al. Among authors: kirkpatrick l. Mol Cancer Ther. 2004 Jul;3(7):763-72. Mol Cancer Ther. 2004. PMID: 15252137

2

Antitumor activity and pharmacodynamic properties of PX-478, an inhibitor of hypoxia-inducible factor-1alpha.

Welsh S, Williams R, Kirkpatrick L, Paine-Murrieta G, Powis G. Welsh S, et al. Among authors: kirkpatrick l. Mol Cancer Ther. 2004 Mar;3(3):233-44. Mol Cancer Ther. 2004. PMID: 15026543

3

Hypoxia inducible factor-1alpha as a cancer drug target.

Powis G, Kirkpatrick L. Powis G, et al. Among authors: kirkpatrick l. Mol Cancer Ther. 2004 May;3(5):647-54. Mol Cancer Ther. 2004. PMID: 15141023 Review.

4

Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin.

Wipf P, Minion DJ, Halter RJ, Berggren MI, Ho CB, Chiang GG, Kirkpatrick L, Abraham R, Powis G. Wipf P, et al. Among authors: kirkpatrick l. Org Biomol Chem. 2004 Jul 7;2(13):1911-20. doi: 10.1039/b405431h. Epub 2004 Jun 14. Org Biomol Chem. 2004. PMID: 15227545

5

In vivo molecular pharmacology and antitumor activity of the targeted Akt inhibitor PX-316.

Meuillet EJ, Ihle N, Baker AF, Gard JM, Stamper C, Williams R, Coon A, Mahadevan D, George BL, Kirkpatrick L, Powis G. Meuillet EJ, et al. Among authors: kirkpatrick l. Oncol Res. 2004;14(10):513-27. doi: 10.3727/0965040042380487. Oncol Res. 2004. PMID: 15559765

6

Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

Jordan BF, Runquist M, Raghunand N, Baker A, Williams R, Kirkpatrick L, Powis G, Gillies RJ. Jordan BF, et al. Among authors: kirkpatrick l. Neoplasia. 2005 May;7(5):475-85. doi: 10.1593/neo.04628. Neoplasia. 2005. PMID: 15967100 Free PMC article.

7

The skin and hair as surrogate tissues for measuring the target effect of inhibitors of phosphoinositide-3-kinase signaling.

Williams R, Baker AF, Ihle NT, Winkler AR, Kirkpatrick L, Powis G. Williams R, et al. Among authors: kirkpatrick l. Cancer Chemother Pharmacol. 2006 Oct;58(4):444-50. doi: 10.1007/s00280-006-0190-0. Epub 2006 Feb 17. Cancer Chemother Pharmacol. 2006. PMID: 16485116 Free PMC article.

8

Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity.

Ihle NT, Lemos R, Schwartz D, Oh J, Halter RJ, Wipf P, Kirkpatrick L, Powis G. Ihle NT, et al. Among authors: kirkpatrick l. Mol Cancer Ther. 2009 Jan;8(1):94-100. doi: 10.1158/1535-7163.MCT-08-0714. Mol Cancer Ther. 2009. PMID: 19139117 Free PMC article.

9

Treatment with HIF-1alpha antagonist PX-478 inhibits progression and spread of orthotopic human small cell lung cancer and lung adenocarcinoma in mice.

Jacoby JJ, Erez B, Korshunova MV, Williams RR, Furutani K, Takahashi O, Kirkpatrick L, Lippman SM, Powis G, O'Reilly MS, Herbst RS. Jacoby JJ, et al. Among authors: kirkpatrick l. J Thorac Oncol. 2010 Jul;5(7):940-9. doi: 10.1097/JTO.0b013e3181dc211f. J Thorac Oncol. 2010. PMID: 20512076 Free PMC article.

10

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.

Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G. Indarte M, et al. Among authors: kirkpatrick l. Cancer Res. 2019 Jun 15;79(12):3100-3111. doi: 10.1158/0008-5472.CAN-18-2372. Epub 2019 Apr 30. Cancer Res. 2019. PMID: 31040156 Free PMC article.

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