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HACE1 reduces oxidative stress and mutant Huntingtin toxicity by promoting the NRF2 response.
Rotblat B, Southwell AL, Ehrnhoefer DE, Skotte NH, Metzler M, Franciosi S, Leprivier G, Somasekharan SP, Barokas A, Deng Y, Tang T, Mathers J, Cetinbas N, Daugaard M, Kwok B, Li L, Carnie CJ, Fink D, Nitsch R, Galpin JD, Ahern CA, Melino G, Penninger JM, Hayden MR, Sorensen PH. Rotblat B, et al. Among authors: penninger jm. Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3032-7. doi: 10.1073/pnas.1314421111. Epub 2014 Feb 10. Proc Natl Acad Sci U S A. 2014. PMID: 24516159 Free PMC article.
The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate.
Tortola L, Nitsch R, Bertrand MJM, Kogler M, Redouane Y, Kozieradzki I, Uribesalgo I, Fennell LM, Daugaard M, Klug H, Wirnsberger G, Wimmer R, Perlot T, Sarao R, Rao S, Hanada T, Takahashi N, Kernbauer E, Demiröz D, Lang M, Superti-Furga G, Decker T, Pichler A, Ikeda F, Kroemer G, Vandenabeele P, Sorensen PH, Penninger JM. Tortola L, et al. Among authors: penninger jm. Cell Rep. 2016 May 17;15(7):1481-1492. doi: 10.1016/j.celrep.2016.04.032. Epub 2016 May 5. Cell Rep. 2016. PMID: 27160902 Free PMC article.
HACE1 Prevents Lung Carcinogenesis via Inhibition of RAC-Family GTPases.
Kogler M, Tortola L, Negri GL, Leopoldi A, El-Naggar AM, Mereiter S, Gomez-Diaz C, Nitsch R, Tortora D, Kavirayani AM, Gapp BV, Rao S, Uribesalgo I, Hoffmann D, Cikes D, Novatchkova M, Williams DA, Trent JM, Ikeda F, Daugaard M, Hagelkruys A, Sorensen PH, Penninger JM. Kogler M, et al. Cancer Res. 2020 Jul 15;80(14):3009-3022. doi: 10.1158/0008-5472.CAN-19-2270. Epub 2020 May 4. Cancer Res. 2020. PMID: 32366477 Free PMC article.
HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner.
Turgu B, Zhang F, El-Naggar A, Negri GL, Kogler M, Tortola L, Johnson F, Ng T, Li A, Yapp D, Lockwood W, Martinez D, Maris JM, Daugaard M, Penninger JM, Hughes CS, Sorensen PH. Turgu B, et al. Oncogene. 2021 Mar;40(11):1988-2001. doi: 10.1038/s41388-021-01680-1. Epub 2021 Feb 18. Oncogene. 2021. PMID: 33603169 Free PMC article.
657 results