Cohen LH - Search Results

1

Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1.

El Oualid F, Burm BE, Leroy IM, Cohen LH, van Boom JH, van den Elst H, Overkleeft HS, van der Marel GA, Overhand M. El Oualid F, et al. Among authors: cohen lh. J Med Chem. 2004 Jul 29;47(16):3920-3. doi: 10.1021/jm049927q. J Med Chem. 2004. PMID: 15267228

2

Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1.

El Oualid F, Baktawar J, Leroy IM, van den Elst H, Cohen LH, van der Marel GA, Overkleeft HS, Overhand M. El Oualid F, et al. Among authors: cohen lh. Bioorg Med Chem. 2005 Mar 1;13(5):1463-75. doi: 10.1016/j.bmc.2004.12.035. Bioorg Med Chem. 2005. PMID: 15698762

3

A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1.

El Oualid F, van den Elst H, Leroy IM, Pieterman E, Cohen LH, Burm BE, Overkleeft HS, van der Marel GA, Overhand M. El Oualid F, et al. Among authors: cohen lh. J Comb Chem. 2005 Sep-Oct;7(5):703-13. doi: 10.1021/cc0500203. J Comb Chem. 2005. PMID: 16153065

4

Inhibitors of protein: geranylgeranyl transferases.

El Oualid F, Cohen LH, van der Marel GA, Overhand M. El Oualid F, et al. Among authors: cohen lh. Curr Med Chem. 2006;13(20):2385-427. doi: 10.2174/092986706777935078. Curr Med Chem. 2006. PMID: 16918362 Review.

5

Inhibition of human smooth muscle cell proliferation in culture by farnesyl pyrophosphate analogues, inhibitors of in vitro protein: farnesyl transferase.

Cohen LH, Pieterman E, van Leeuwen RE, Du J, Negre-Aminou P, Valentijn AR, Overhand M, van der Marel GA, van Boom JH. Cohen LH, et al. Biochem Pharmacol. 1999 Feb 15;57(4):365-73. doi: 10.1016/s0006-2952(98)00322-0. Biochem Pharmacol. 1999. PMID: 9933024

6

Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics.

Cohen LH, Pieterman E, van Leeuwen RE, Overhand M, Burm BE, van der Marel GA, van Boom JH. Cohen LH, et al. Biochem Pharmacol. 2000 Oct 15;60(8):1061-8. doi: 10.1016/s0006-2952(00)00386-5. Biochem Pharmacol. 2000. PMID: 11007942 Review.

7

Different analogues of farnesyl pyrophosphate inhibit squalene synthase and protein:farnesyltransferase to different extents.

Cohen LH, Valentijn AR, Roodenburg L, Van Leeuwen RE, Huisman RH, Lutz RJ, Van der Marel GA, Van Boom JH. Cohen LH, et al. Biochem Pharmacol. 1995 Mar 15;49(6):839-45. doi: 10.1016/0006-2952(94)00454-t. Biochem Pharmacol. 1995. PMID: 7702642

8

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates.

van Beek ER, Cohen LH, Leroy IM, Ebetino FH, Löwik CW, Papapoulos SE. van Beek ER, et al. Among authors: cohen lh. Bone. 2003 Nov;33(5):805-11. doi: 10.1016/j.bone.2003.07.007. Bone. 2003. PMID: 14623056

9

Inhibition of proliferation of human smooth muscle cells by various HMG-CoA reductase inhibitors; comparison with other human cell types.

Nègre-Aminou P, van Vliet AK, van Erck M, van Thiel GC, van Leeuwen RE, Cohen LH. Nègre-Aminou P, et al. Among authors: cohen lh. Biochim Biophys Acta. 1997 Apr 21;1345(3):259-68. doi: 10.1016/s0005-2760(96)00184-1. Biochim Biophys Acta. 1997. PMID: 9150246

10

Vastatins have a distinct effect on sterol synthesis and progesterone secretion in human granulosa cells in vitro.

van Vliet AK, van Thiel GC, Naaktgeboren N, Cohen LH. van Vliet AK, et al. Among authors: cohen lh. Biochim Biophys Acta. 1996 Jun 11;1301(3):237-41. doi: 10.1016/0005-2760(96)00010-0. Biochim Biophys Acta. 1996. PMID: 8664334

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