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Page 1
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
Kohrt JT, Filipski KJ, Cody WL, Cai C, Dudley DA, Van Huis CA, Willardsen JA, Rapundalo ST, Saiya-Cork K, Leadley RJ, Narasimhan L, Zhang E, Whitlow M, Adler M, McLean K, Chou YL, McKnight C, Arnaiz DO, Shaw KJ, Light DR, Edmunds JJ. Kohrt JT, et al. Among authors: cody wl. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4752-6. doi: 10.1016/j.bmcl.2005.07.059. Bioorg Med Chem Lett. 2005. PMID: 16125385
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.
Kohrt JT, Filipski KJ, Cody WL, Cai C, Dudley DA, Van Huis CA, Willardsen JA, Narasimhan LS, Zhang E, Rapundalo ST, Saiya-Cork K, Leadley RJ, Edmunds JJ. Kohrt JT, et al. Among authors: cody wl. Bioorg Med Chem Lett. 2006 Feb 15;16(4):1060-4. doi: 10.1016/j.bmcl.2005.10.076. Epub 2005 Nov 11. Bioorg Med Chem Lett. 2006. PMID: 16289811
The discovery of glycine and related amino acid-based factor Xa inhibitors.
Kohrt JT, Filipski KJ, Cody WL, Bigge CF, La F, Welch K, Dahring T, Bryant JW, Leonard D, Bolton G, Narasimhan L, Zhang E, Peterson JT, Haarer S, Sahasrabudhe V, Janiczek N, Desiraju S, Hena M, Fiakpui C, Saraswat N, Sharma R, Sun S, Maiti SN, Leadley R, Edmunds JJ. Kohrt JT, et al. Among authors: cody wl. Bioorg Med Chem. 2006 Jul 1;14(13):4379-92. doi: 10.1016/j.bmc.2006.02.040. Epub 2006 Mar 10. Bioorg Med Chem. 2006. PMID: 16529937
The discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an orally efficacious factor Xa inhibitor.
Kohrt JT, Bigge CF, Bryant JW, Casimiro-Garcia A, Chi L, Cody WL, Dahring T, Dudley DA, Filipski KJ, Haarer S, Heemstra R, Janiczek N, Narasimhan L, McClanahan T, Peterson JT, Sahasrabudhe V, Schaum R, Van Huis CA, Welch KM, Zhang E, Leadley RJ, Edmunds JJ. Kohrt JT, et al. Among authors: cody wl. Chem Biol Drug Des. 2007 Aug;70(2):100-12. doi: 10.1111/j.1747-0285.2007.00539.x. Chem Biol Drug Des. 2007. PMID: 17683371
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action.
Van Huis CA, Casimiro-Garcia A, Bigge CF, Cody WL, Dudley DA, Filipski KJ, Heemstra RJ, Kohrt JT, Leadley RJ Jr, Narasimhan LS, McClanahan T, Mochalkin I, Pamment M, Peterson JT, Sahasrabudhe V, Schaum RP, Edmunds JJ. Van Huis CA, et al. Among authors: cody wl. Bioorg Med Chem. 2009 Mar 15;17(6):2501-11. doi: 10.1016/j.bmc.2009.01.063. Epub 2009 Feb 3. Bioorg Med Chem. 2009. PMID: 19231206
Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.
Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD. Plummer JS, et al. Among authors: cody wl. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3409-14. doi: 10.1016/s0960-894x(98)00613-1. Bioorg Med Chem Lett. 1998. PMID: 9873743
Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.
Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Eaton S, Edmunds JJ, Holland DR, Lafleur D, Levesque S, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser A, St-Denis Y, Winocour P. Plummer JS, et al. Among authors: cody wl. Bioorg Med Chem Lett. 1999 Mar 22;9(6):835-40. doi: 10.1016/s0960-894x(99)00096-7. Bioorg Med Chem Lett. 1999. PMID: 10206546
61 results