Edmunds JJ - Search Results

1

Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.

Willardsen JA, Dudley DA, Cody WL, Chi L, McClanahan TB, Mertz TE, Potoczak RE, Narasimhan LS, Holland DR, Rapundalo ST, Edmunds JJ. Willardsen JA, et al. Among authors: edmunds jj. J Med Chem. 2004 Jul 29;47(16):4089-99. doi: 10.1021/jm0497491. J Med Chem. 2004. PMID: 15267248

2

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

Edmunds JJ, Klutchko S, Hamby JM, Bunker AM, Connolly CJ, Winters RT, Quin J 3rd, Sircar I, Hodges JC, Panek RL, et al. Edmunds JJ, et al. J Med Chem. 1995 Sep 15;38(19):3759-71. doi: 10.1021/jm00019a005. J Med Chem. 1995. PMID: 7562906

3

Discovery of a novel series of orally active non-peptide endothelin-A (ETA) receptor-selective antagonists.

Doherty AM, Patt WC, Edmunds JJ, Berryman KA, Reisdorph BR, Plummer MS, Shahripour A, Lee C, Cheng XM, Walker DM, et al. Doherty AM, et al. Among authors: edmunds jj. J Med Chem. 1995 Apr 14;38(8):1259-63. doi: 10.1021/jm00008a002. J Med Chem. 1995. PMID: 7731010 No abstract available.

4

Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoroacetyl)-1H-pyrrol-1-yl]-1H- imidazole-5-carboxylic acid (CI-996).

Sircar I, Hodges JC, Quin J 3rd, Bunker AM, Winters RT, Edmunds JJ, Kostlan CR, Connolly C, Kesten SJ, Hamby JM, et al. Sircar I, et al. Among authors: edmunds jj. J Med Chem. 1993 Aug 6;36(16):2253-65. doi: 10.1021/jm00068a002. J Med Chem. 1993. PMID: 8360871

5

Structure-activity relationships in a series of orally active gamma-hydroxy butenolide endothelin antagonists.

Patt WC, Edmunds JJ, Repine JT, Berryman KA, Reisdorph BR, Lee C, Plummer MS, Shahripour A, Haleen SJ, Keiser JA, Flynn MA, Welch KM, Reynolds EE, Rubin R, Tobias B, Hallak H, Doherty AM. Patt WC, et al. Among authors: edmunds jj. J Med Chem. 1997 Mar 28;40(7):1063-74. doi: 10.1021/jm9606507. J Med Chem. 1997. PMID: 9089328

6

Endothelin receptor antagonists: synthesis and structure-activity relationships of substituted benzothiazine-1,1-dioxides.

Berryman KA, Edmunds JJ, Bunker AM, Haleen S, Bryant J, Welch KM, Doherty AM. Berryman KA, et al. Among authors: edmunds jj. Bioorg Med Chem. 1998 Sep;6(9):1447-56. doi: 10.1016/s0968-0896(98)00080-7. Bioorg Med Chem. 1998. PMID: 9801816

7

Potent bicyclic lactam inhibitors of thrombin: Part I: P3 modifications.

St-Denis Y, Augelli-Szafran CE, Bachand B, Berryman KA, DiMaio J, Doherty AM, Edmunds JJ, Leblond L, Lévesque S, Narasimhan LS, Penvose-Yi JR, Rubin JR, Tarazi M, Winocour PD, Siddiqui MA. St-Denis Y, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 1998 Nov 17;8(22):3193-8. doi: 10.1016/s0960-894x(98)00550-2. Bioorg Med Chem Lett. 1998. PMID: 9873701

8

Potent and selective bicyclic lactam inhibitors of thrombin: Part 2: P1 modifications.

Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Edmunds JJ, He JX, Holland DR, Levesque S, Kent DR, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser AJ, St-Denis Y, Winocour PD. Plummer JS, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 1998 Dec 1;8(23):3409-14. doi: 10.1016/s0960-894x(98)00613-1. Bioorg Med Chem Lett. 1998. PMID: 9873743

9

Potent and selective bicyclic lactam inhibitors of thrombin: Part 3: P1' modifications.

Plummer JS, Berryman KA, Cai C, Cody WL, DiMaio J, Doherty AM, Eaton S, Edmunds JJ, Holland DR, Lafleur D, Levesque S, Narasimhan LS, Rubin JR, Rapundalo ST, Siddiqui MA, Susser A, St-Denis Y, Winocour P. Plummer JS, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 1999 Mar 22;9(6):835-40. doi: 10.1016/s0960-894x(99)00096-7. Bioorg Med Chem Lett. 1999. PMID: 10206546

10

The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 1.

Cody WL, Cai C, Doherty AM, Edmunds JJ, He JX, Narasimhan LS, Plummer JS, Rapundalo ST, Rubin JR, Van Huis CA, St-Denis Y, Winocour PD, Siddiqui MA. Cody WL, et al. Among authors: edmunds jj. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2497-502. doi: 10.1016/s0960-894x(99)00418-7. Bioorg Med Chem Lett. 1999. PMID: 10498196

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