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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.
Hazuda DJ, Anthony NJ, Gomez RP, Jolly SM, Wai JS, Zhuang L, Fisher TE, Embrey M, Guare JP Jr, Egbertson MS, Vacca JP, Huff JR, Felock PJ, Witmer MV, Stillmock KA, Danovich R, Grobler J, Miller MD, Espeseth AS, Jin L, Chen IW, Lin JH, Kassahun K, Ellis JD, Wong BK, Xu W, Pearson PG, Schleif WA, Cortese R, Emini E, Summa V, Holloway MK, Young SD. Hazuda DJ, et al. Among authors: huff jr. Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11233-8. doi: 10.1073/pnas.0402357101. Epub 2004 Jul 26. Proc Natl Acad Sci U S A. 2004. PMID: 15277684 Free PMC article.
Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
Dorsey BD, McDonough C, McDaniel SL, Levin RB, Newton CL, Hoffman JM, Darke PL, Zugay-Murphy JA, Emini EA, Schleif WA, Olsen DB, Stahlhut MW, Rutkowski CA, Kuo LC, Lin JH, Chen IW, Michelson SR, Holloway MK, Huff JR, Vacca JP. Dorsey BD, et al. Among authors: huff jr. J Med Chem. 2000 Sep 7;43(18):3386-99. doi: 10.1021/jm9903848. J Med Chem. 2000. PMID: 10978186
Metabolism of synthetic inositol trisphosphate analogs.
Polokoff MA, Bencen GH, Vacca JP, deSolms SJ, Young SD, Huff JR. Polokoff MA, et al. Among authors: huff jr. J Biol Chem. 1988 Aug 25;263(24):11922-7. J Biol Chem. 1988. PMID: 2841338 Free article.
[3H]L-654,284 as a probe of the central alpha 2 adrenoceptor.
Randall WC, Huff JR, Vacca JP, Guare JP, Chen R, Rosegay A, Baldwin JJ. Randall WC, et al. Among authors: huff jr. Naunyn Schmiedebergs Arch Pharmacol. 1988 Jul;338(1):47-52. doi: 10.1007/BF00168811. Naunyn Schmiedebergs Arch Pharmacol. 1988. PMID: 2907099
45 results