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Page 1
Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits.
Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S. Yao J, et al. Among authors: holtzman dm. J Neurochem. 2004 Aug;90(4):1011-8. doi: 10.1111/j.1471-4159.2004.02532.x. J Neurochem. 2004. PMID: 15287908 Free article.
Alzheimer's Abeta vaccination of rhesus monkeys (Macaca mulatta).
Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, St George Hyslop P, Holtzman DM, Walker LC, Keller ET. Gandy S, et al. Among authors: holtzman dm. Mech Ageing Dev. 2004 Feb;125(2):149-51. doi: 10.1016/j.mad.2003.12.002. Mech Ageing Dev. 2004. PMID: 15037022
Alzheimer A beta vaccination of rhesus monkeys (Macaca mulatta).
Gandy S, DeMattos RB, Lemere CA, Heppner FL, Leverone J, Aguzzi A, Ershler WB, Dai J, Fraser P, Hyslop PS, Holtzman DM, Walker LC, Keller ET. Gandy S, et al. Among authors: holtzman dm. Alzheimer Dis Assoc Disord. 2004 Jan-Mar;18(1):44-6. doi: 10.1097/00002093-200401000-00009. Alzheimer Dis Assoc Disord. 2004. PMID: 15195463
A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.
Sadowski M, Pankiewicz J, Scholtzova H, Ripellino JA, Li Y, Schmidt SD, Mathews PM, Fryer JD, Holtzman DM, Sigurdsson EM, Wisniewski T. Sadowski M, et al. Among authors: holtzman dm. Am J Pathol. 2004 Sep;165(3):937-48. doi: 10.1016/s0002-9440(10)63355-x. Am J Pathol. 2004. PMID: 15331417 Free PMC article.
ApoE promotes the proteolytic degradation of Abeta.
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. Jiang Q, et al. Among authors: holtzman dm. Neuron. 2008 Jun 12;58(5):681-93. doi: 10.1016/j.neuron.2008.04.010. Neuron. 2008. PMID: 18549781 Free PMC article.
Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction.
Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Leverenz J, Fagan A, Goate A, Bateman R, Holtzman DM, Yamamoto T, Nakaya T, Gandy S, Suzuki T. Hata S, et al. Among authors: holtzman dm. Ann Neurol. 2011 Jun;69(6):1026-31. doi: 10.1002/ana.22343. Ann Neurol. 2011. PMID: 21681798 Free PMC article.
Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects.
Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Sohrabi HR, Martins RN, Gandy S, Urakami K, Suzuki T; Japanese Alzheimer's Disease Neuroimaging Initiative. Hata S, et al. Among authors: holtzman dm. Mol Neurodegener. 2012 Apr 25;7:16. doi: 10.1186/1750-1326-7-16. Mol Neurodegener. 2012. PMID: 22534039 Free PMC article.
The future of blood-based biomarkers for Alzheimer's disease.
Henriksen K, O'Bryant SE, Hampel H, Trojanowski JQ, Montine TJ, Jeromin A, Blennow K, Lönneborg A, Wyss-Coray T, Soares H, Bazenet C, Sjögren M, Hu W, Lovestone S, Karsdal MA, Weiner MW; Blood-Based Biomarker Interest Group. Henriksen K, et al. Alzheimers Dement. 2014 Jan;10(1):115-31. doi: 10.1016/j.jalz.2013.01.013. Epub 2013 Jul 11. Alzheimers Dement. 2014. PMID: 23850333 Free PMC article. Review.
724 results