Sun H - Search Results

1

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Tomita Y, Krajewski K, Roller PP, Wang S. Sun H, et al. J Med Chem. 2004 Aug 12;47(17):4147-50. doi: 10.1021/jm0499108. J Med Chem. 2004. PMID: 15293984

2

Structure-based design of potent, conformationally constrained Smac mimetics.

Sun H, Nikolovska-Coleska Z, Yang CY, Xu L, Liu M, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. J Am Chem Soc. 2004 Dec 29;126(51):16686-7. doi: 10.1021/ja047438+. J Am Chem Soc. 2004. PMID: 15612682

3

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

Sun H, Nikolovska-Coleska Z, Chen J, Yang CY, Tomita Y, Pan H, Yoshioka Y, Krajewski K, Roller PP, Wang S. Sun H, et al. Bioorg Med Chem Lett. 2005 Feb 1;15(3):793-7. doi: 10.1016/j.bmcl.2004.11.008. Bioorg Med Chem Lett. 2005. PMID: 15664859

4

Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic.

Sun H, Nikolovska-Coleska Z, Lu J, Qiu S, Yang CY, Gao W, Meagher J, Stuckey J, Wang S. Sun H, et al. J Med Chem. 2006 Dec 28;49(26):7916-20. doi: 10.1021/jm061108d. J Med Chem. 2006. PMID: 17181177

5

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP.

Sun H, Nikolovska-Coleska Z, Lu J, Meagher JL, Yang CY, Qiu S, Tomita Y, Ueda Y, Jiang S, Krajewski K, Roller PP, Stuckey JA, Wang S. Sun H, et al. J Am Chem Soc. 2007 Dec 12;129(49):15279-94. doi: 10.1021/ja074725f. Epub 2007 Nov 14. J Am Chem Soc. 2007. PMID: 17999504 Free PMC article.

6

Design of small-molecule peptidic and nonpeptidic Smac mimetics.

Sun H, Nikolovska-Coleska Z, Yang CY, Qian D, Lu J, Qiu S, Bai L, Peng Y, Cai Q, Wang S. Sun H, et al. Acc Chem Res. 2008 Oct;41(10):1264-77. doi: 10.1021/ar8000553. Acc Chem Res. 2008. PMID: 18937395 Free PMC article.

7

Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP).

Sun H, Stuckey JA, Nikolovska-Coleska Z, Qin D, Meagher JL, Qiu S, Lu J, Yang CY, Saito NG, Wang S. Sun H, et al. J Med Chem. 2008 Nov 27;51(22):7169-80. doi: 10.1021/jm8006849. J Med Chem. 2008. PMID: 18954041 Free PMC article.

8

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

Lu J, Bai L, Sun H, Nikolovska-Coleska Z, McEachern D, Qiu S, Miller RS, Yi H, Shangary S, Sun Y, Meagher JL, Stuckey JA, Wang S. Lu J, et al. Among authors: sun y, sun h. Cancer Res. 2008 Nov 15;68(22):9384-93. doi: 10.1158/0008-5472.CAN-08-2655. Cancer Res. 2008. PMID: 19010913 Free PMC article.

9

Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases.

Zhang B, Nikolovska-Coleska Z, Zhang Y, Bai L, Qiu S, Yang CY, Sun H, Wang S, Wu Y. Zhang B, et al. Among authors: sun h. J Med Chem. 2008 Dec 11;51(23):7352-5. doi: 10.1021/jm801146d. J Med Chem. 2008. PMID: 19012392 Free PMC article.

10

Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.

Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D, Wang S. Peng Y, et al. Among authors: sun h. J Med Chem. 2008 Dec 25;51(24):8158-62. doi: 10.1021/jm801254r. J Med Chem. 2008. PMID: 19049347 Free PMC article.

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