Khosla C - Search Results

1

Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway.

Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Lee HY, et al. Among authors: khosla c. J Am Chem Soc. 2004 Aug 18;126(32):9924-5. doi: 10.1021/ja048836f. J Am Chem Soc. 2004. PMID: 15303858

2

Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases.

Pieper R, Luo G, Cane DE, Khosla C. Pieper R, et al. Among authors: khosla c. Nature. 1995 Nov 16;378(6554):263-6. doi: 10.1038/378263a0. Nature. 1995. PMID: 7477343

3

A new enzyme superfamily - the phosphopantetheinyl transferases.

Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. Lambalot RH, et al. Among authors: khosla c. Chem Biol. 1996 Nov;3(11):923-36. doi: 10.1016/s1074-5521(96)90181-7. Chem Biol. 1996. PMID: 8939709

4

Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase.

Carreras CW, Gehring AM, Walsh CT, Khosla C. Carreras CW, et al. Among authors: khosla c. Biochemistry. 1997 Sep 30;36(39):11757-61. doi: 10.1021/bi971350+. Biochemistry. 1997. PMID: 9305965

5

Harnessing the biosynthetic code: combinations, permutations, and mutations.

Cane DE, Walsh CT, Khosla C. Cane DE, et al. Among authors: khosla c. Science. 1998 Oct 2;282(5386):63-8. doi: 10.1126/science.282.5386.63. Science. 1998. PMID: 9756477 Review.

6

The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates.

Admiraal SJ, Walsh CT, Khosla C. Admiraal SJ, et al. Among authors: khosla c. Biochemistry. 2001 May 22;40(20):6116-23. doi: 10.1021/bi010080z. Biochemistry. 2001. PMID: 11352749

7

Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors.

Pohl NL, Hans M, Lee HY, Kim YS, Cane DE, Khosla C. Pohl NL, et al. Among authors: khosla c. J Am Chem Soc. 2001 Jun 20;123(24):5822-3. doi: 10.1021/ja0028368. J Am Chem Soc. 2001. PMID: 11403625 No abstract available.

8

Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules.

Wu N, Tsuji SY, Cane DE, Khosla C. Wu N, et al. Among authors: khosla c. J Am Chem Soc. 2001 Jul 11;123(27):6465-74. doi: 10.1021/ja010219t. J Am Chem Soc. 2001. PMID: 11439032

9

Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster.

Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C. Chiu HT, et al. Among authors: khosla c. Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8548-53. doi: 10.1073/pnas.151246498. Epub 2001 Jul 10. Proc Natl Acad Sci U S A. 2001. PMID: 11447274 Free PMC article.

10

Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase.

Kinoshita K, Williard PG, Khosla C, Cane DE. Kinoshita K, et al. Among authors: khosla c. J Am Chem Soc. 2001 Mar 21;123(11):2495-502. doi: 10.1021/ja004139l. J Am Chem Soc. 2001. PMID: 11456917

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