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Central mechanisms regulating penile erection in conscious rats: the dopaminergic systems related to the proerectile effect of apomorphine.
Hsieh GC, Hollingsworth PR, Martino B, Chang R, Terranova MA, O'Neill AB, Lynch JJ, Moreland RB, Donnelly-Roberts DL, Kolasa T, Mikusa JP, McVey JM, Marsh KC, Sullivan JP, Brioni JD. Hsieh GC, et al. Among authors: moreland rb. J Pharmacol Exp Ther. 2004 Jan;308(1):330-8. doi: 10.1124/jpet.103.057455. Epub 2003 Oct 20. J Pharmacol Exp Ther. 2004. PMID: 14569075
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.
Stewart AO, Cowart MD, Moreland RB, Latshaw SP, Matulenko MA, Bhatia PA, Wang X, Daanen JF, Nelson SL, Terranova MA, Namovic MT, Donnelly-Roberts DL, Miller LN, Nakane M, Sullivan JP, Brioni JD. Stewart AO, et al. Among authors: moreland rb. J Med Chem. 2004 Apr 22;47(9):2348-55. doi: 10.1021/jm0305669. J Med Chem. 2004. PMID: 15084133
Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.
Brioni JD, Moreland RB, Cowart M, Hsieh GC, Stewart AO, Hedlund P, Donnelly-Roberts DL, Nakane M, Lynch JJ 3rd, Kolasa T, Polakowski JS, Osinski MA, Marsh K, Andersson KE, Sullivan JP. Brioni JD, et al. Among authors: moreland rb. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6758-63. doi: 10.1073/pnas.0308292101. Epub 2004 Apr 15. Proc Natl Acad Sci U S A. 2004. PMID: 15087502 Free PMC article.
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
Cowart M, Latshaw SP, Bhatia P, Daanen JF, Rohde J, Nelson SL, Patel M, Kolasa T, Nakane M, Uchic ME, Miller LN, Terranova MA, Chang R, Donnelly-Roberts DL, Namovic MT, Hollingsworth PR, Martino BR, Lynch JJ 3rd, Sullivan JP, Hsieh GC, Moreland RB, Brioni JD, Stewart AO. Cowart M, et al. Among authors: moreland rb. J Med Chem. 2004 Jul 15;47(15):3853-64. doi: 10.1021/jm030505a. J Med Chem. 2004. PMID: 15239663
Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.
Matulenko MA, Surber B, Fan L, Kolasa T, Nakane M, Terranova MA, Uchic ME, Miller LN, Chang R, Donnelly-Roberts DL, Namovic MT, Moreland RB, Brioni JD, Stewart AO. Matulenko MA, et al. Among authors: moreland rb. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5095-8. doi: 10.1016/j.bmcl.2004.07.068. Bioorg Med Chem Lett. 2004. PMID: 15380206
124 results