Reeves LM - Search Results

1

3-Hydroxy-4-arylsulfonyltetrahydropyranyl-3-hydroxamic acids are novel inhibitors of MMP-13 and aggrecanase.

Noe MC, Snow SL, Wolf-Gouveia LA, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Liras JL, Vaughn M. Noe MC, et al. Among authors: reeves lm. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4727-30. doi: 10.1016/j.bmcl.2004.06.081. Bioorg Med Chem Lett. 2004. PMID: 15324896

2

Synthesis and biological activity of piperazine-based dual MMP-13 and TNF-alpha converting enzyme inhibitors.

Letavic MA, Barberia JT, Carty TJ, Hardink JR, Liras J, Lopresti-Morrow LL, Mitchell PG, Noe MC, Reeves LM, Snow SL, Stam EJ, Sweeney FJ, Vaughn ML, Yu CH. Letavic MA, et al. Among authors: reeves lm. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3243-6. doi: 10.1016/s0960-894x(03)00666-8. Bioorg Med Chem Lett. 2003. PMID: 12951101

3

Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.

Noe MC, Natarajan V, Snow SL, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Carty TJ, Barberia JA, Sweeney FJ, Liras JL, Vaughn M, Hardink JR, Hawkins JM, Tokar C. Noe MC, et al. Among authors: reeves lm. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2808-11. doi: 10.1016/j.bmcl.2005.03.105. Bioorg Med Chem Lett. 2005. PMID: 15911259

4

Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.

Noe MC, Natarajan V, Snow SL, Wolf-Gouveia LA, Mitchell PG, Lopresti-Morrow L, Reeves LM, Yocum SA, Otterness I, Bliven MA, Carty TJ, Barberia JT, Sweeney FJ, Liras JL, Vaughn M. Noe MC, et al. Among authors: reeves lm. Bioorg Med Chem Lett. 2005 Jul 15;15(14):3385-8. doi: 10.1016/j.bmcl.2005.05.037. Bioorg Med Chem Lett. 2005. PMID: 15953722

5

Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.

Letavic MA, Axt MZ, Barberia JT, Carty TJ, Danley DE, Geoghegan KF, Halim NS, Hoth LR, Kamath AV, Laird ER, Lopresti-Morrow LL, McClure KF, Mitchell PG, Natarajan V, Noe MC, Pandit J, Reeves L, Schulte GK, Snow SL, Sweeney FJ, Tan DH, Yu CH. Letavic MA, et al. Bioorg Med Chem Lett. 2002 May 20;12(10):1387-90. doi: 10.1016/s0960-894x(02)00183-x. Bioorg Med Chem Lett. 2002. PMID: 11992783

6

Inhibition of MMP-1 and MMP-13 with phosphinic acids that exploit binding in the S2 pocket.

Reiter LA, Rizzi JP, Pandit J, Lasut MJ, McGahee SM, Parikh VD, Blake JF, Danley DE, Laird ER, Lopez-Anaya A, Lopresti-Morrow LL, Mansour MN, Martinelli GJ, Mitchell PG, Owens BS, Pauly TA, Reeves LM, Schulte GK, Yocum SA. Reiter LA, et al. Among authors: reeves lm. Bioorg Med Chem Lett. 1999 Jan 18;9(2):127-32. doi: 10.1016/s0960-894x(98)00729-x. Bioorg Med Chem Lett. 1999. PMID: 10021913

7

Structure-based design and synthesis of a potent matrix metalloproteinase-13 inhibitor based on a pyrrolidinone scaffold.

Robinson RP, Laird ER, Blake JF, Bordner J, Donahue KM, Lopresti-Morrow LL, Mitchell PG, Reese MR, Reeves LM, Stam EJ, Yocum SA. Robinson RP, et al. Among authors: reeves lm. J Med Chem. 2000 Jun 15;43(12):2293-6. doi: 10.1021/jm0001368. J Med Chem. 2000. PMID: 10882354 No abstract available.

8

Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors.

Robinson RP, Laird ER, Donahue KM, Lopresti-Morrow LL, Mitchell PG, Reese MR, Reeves LM, Rouch AI, Stam EJ, Yocum SA. Robinson RP, et al. Among authors: reeves lm. Bioorg Med Chem Lett. 2001 May 7;11(9):1211-3. doi: 10.1016/s0960-894x(01)00187-1. Bioorg Med Chem Lett. 2001. PMID: 11354379

9

MMP-13 and MMP-1 expression in tissues of normal articular joints.

Yocum SA, Lopresti-Morrow LL, Reeves LM, Mitchell PG. Yocum SA, et al. Among authors: reeves lm. Ann N Y Acad Sci. 1999 Jun 30;878:583-6. doi: 10.1111/j.1749-6632.1999.tb07734.x. Ann N Y Acad Sci. 1999. PMID: 10415780 No abstract available.

10

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.

Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, Geoghegan KF, Hambor JE. Mitchell PG, et al. Among authors: reeves lm. J Clin Invest. 1996 Feb 1;97(3):761-8. doi: 10.1172/JCI118475. J Clin Invest. 1996. PMID: 8609233 Free PMC article.

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