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3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.
Ellsworth EL, Tran TP, Showalter HD, Sanchez JP, Watson BM, Stier MA, Domagala JM, Gracheck SJ, Joannides ET, Shapiro MA, Dunham SA, Hanna DL, Huband MD, Gage JW, Bronstein JC, Liu JY, Nguyen DQ, Singh R. Ellsworth EL, et al. Among authors: domagala jm. J Med Chem. 2006 Nov 2;49(22):6435-8. doi: 10.1021/jm060505l. J Med Chem. 2006. PMID: 17064062
Structure-activity relationships of 3-aminoquinazolinediones, a new class of bacterial type-2 topoisomerase (DNA gyrase and topo IV) inhibitors.
Tran TP, Ellsworth EL, Sanchez JP, Watson BM, Stier MA, Showalter HD, Domagala JM, Shapiro MA, Joannides ET, Gracheck SJ, Nguyen DQ, Bird P, Yip J, Sharadendu A, Ha C, Ramezani S, Wu X, Singh R. Tran TP, et al. Among authors: domagala jm. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1312-20. doi: 10.1016/j.bmcl.2006.12.005. Epub 2006 Dec 15. Bioorg Med Chem Lett. 2007. PMID: 17196390
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing achiral 3-(4-amino/carboxamide-2-t-butyl,5-methylphenyl thio) moiety: antiviral activities and pharmacokinetic properties.
Vara Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hagen SE, Markoski LJ, Tait BD, Lunney EA, Tummino PJ, Ferguson D, Holler T, Hupe D, Nouhan C, Gracheck SJ, VanderRoest S, Saunders J, Iyer K, Sinz M, Brodfuehrer J. Vara Prasad JV, et al. Among authors: domagala jm. Bioorg Med Chem Lett. 1999 Jun 7;9(11):1481-6. doi: 10.1016/s0960-894x(99)00237-1. Bioorg Med Chem Lett. 1999. PMID: 10386921
Nonpeptidic HIV protease inhibitors: 6-alkyl-5,6-dihydropyran-2-ones possessing a novel and achiral 3-(2-t-butyl-5-methyl-4-sulfamate)phenylthio moiety.
Vara Prasad JV, Markoski LJ, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hagen SE, Tait BD, Lunney EA, Tummino PJ, Ferguson D, Holler T, Hupe D, Nouhan C, Gracheck SJ, VanderRoest S, Saunders J, Iyer K, Sinz M. Vara Prasad JV, et al. Among authors: domagala jm. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2217-22. doi: 10.1016/s0960-894x(99)00360-1. Bioorg Med Chem Lett. 1999. PMID: 10465549
61 results