Diasio R - Search Results

1

Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration.

Ezzeldin H, Diasio R. Ezzeldin H, et al. Among authors: diasio r. Clin Colorectal Cancer. 2004 Sep;4(3):181-9. doi: 10.3816/ccc.2004.n.018. Clin Colorectal Cancer. 2004. PMID: 15377401 Review.

2

Purification and characterization of dihydropyrimidine dehydrogenase from human liver.

Lu ZH, Zhang R, Diasio RB. Lu ZH, et al. Among authors: diasio rb. J Biol Chem. 1992 Aug 25;267(24):17102-9. J Biol Chem. 1992. PMID: 1512248 Free article.

3

Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome.

Harris BE, Carpenter JT, Diasio RB. Harris BE, et al. Among authors: diasio rb. Cancer. 1991 Aug 1;68(3):499-501. doi: 10.1002/1097-0142(19910801)68:3<499::aid-cncr2820680309>3.0.co;2-f. Cancer. 1991. PMID: 1648430

4

Relationship between dihydropyrimidine dehydrogenase activity and plasma 5-fluorouracil levels with evidence for circadian variation of enzyme activity and plasma drug levels in cancer patients receiving 5-fluorouracil by protracted continuous infusion.

Harris BE, Song R, Soong SJ, Diasio RB. Harris BE, et al. Among authors: diasio rb. Cancer Res. 1990 Jan 1;50(1):197-201. Cancer Res. 1990. PMID: 2293556

5

Clinical pharmacology of 5-fluorouracil.

Diasio RB, Harris BE. Diasio RB, et al. Clin Pharmacokinet. 1989 Apr;16(4):215-37. doi: 10.2165/00003088-198916040-00002. Clin Pharmacokinet. 1989. PMID: 2656050 Review.

6

Circadian rhythm of rat liver dihydropyrimidine dehydrogenase. Possible relevance to fluoropyrimidine chemotherapy.

Harris BE, Song RL, He YJ, Soong SJ, Diasio RB. Harris BE, et al. Among authors: diasio rb. Biochem Pharmacol. 1988 Dec 15;37(24):4759-62. doi: 10.1016/0006-2952(88)90349-8. Biochem Pharmacol. 1988. PMID: 3202908

7

Familial deficiency of dihydropyrimidine dehydrogenase. Biochemical basis for familial pyrimidinemia and severe 5-fluorouracil-induced toxicity.

Diasio RB, Beavers TL, Carpenter JT. Diasio RB, et al. J Clin Invest. 1988 Jan;81(1):47-51. doi: 10.1172/JCI113308. J Clin Invest. 1988. PMID: 3335642 Free PMC article.

8

Population characteristics of hepatic dihydropyrimidine dehydrogenase activity, a key metabolic enzyme in 5-fluorouracil chemotherapy.

Lu Z, Zhang R, Diasio RB. Lu Z, et al. Among authors: diasio rb. Clin Pharmacol Ther. 1995 Nov;58(5):512-22. doi: 10.1016/0009-9236(95)90171-X. Clin Pharmacol Ther. 1995. PMID: 7586945

9

Dihydropyrimidine dehydrogenase activity in human peripheral blood mononuclear cells and liver: population characteristics, newly identified deficient patients, and clinical implication in 5-fluorouracil chemotherapy.

Lu Z, Zhang R, Diasio RB. Lu Z, et al. Among authors: diasio rb. Cancer Res. 1993 Nov 15;53(22):5433-8. Cancer Res. 1993. PMID: 8221682

Sommadossi, D. S. Cross, W. J. Huster, and R. B. Diasio. Cancer Res., 47: 2203-2206, 1987; B. E. Harris, R. Song, S-j. Soong, and R. B. Diasio. Cancer Res., 50: 197-201, 1990), particularly in those with DPD deficiency who experience severe FUra …

Sommadossi, D. S. Cross, W. J. Huster, and R. B. Diasio. Cancer Res., 47: 2203-2206, 1987; B. E. Harris, R. Song, S-j. …

10

Comparison of dihydropyrimidine dehydrogenase from human, rat, pig and cow liver. Biochemical and immunological properties.

Lu ZH, Zhang R, Diasio RB. Lu ZH, et al. Among authors: diasio rb. Biochem Pharmacol. 1993 Sep 1;46(5):945-52. doi: 10.1016/0006-2952(93)90505-q. Biochem Pharmacol. 1993. PMID: 8373446

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