Wang GT - Search Results

1

Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.

Lin NH, Wang L, Wang X, Wang GT, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Lin NH, et al. Among authors: wang x, wang gt, wang l. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5057-62. doi: 10.1016/j.bmcl.2004.07.083. Bioorg Med Chem Lett. 2004. PMID: 15380198

2

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

Wang L, Wang GT, Wang X, Tong Y, Sullivan G, Park D, Leonard NM, Li Q, Cohen J, Gu WZ, Zhang H, Bauch JL, Jakob CG, Hutchins CW, Stoll VS, Marsh K, Rosenberg SH, Sham HL, Lin NH. Wang L, et al. Among authors: wang x, wang gt. J Med Chem. 2004 Jan 29;47(3):612-26. doi: 10.1021/jm030434f. J Med Chem. 2004. PMID: 14736242

3

Synthesis and activity of 1-aryl-1'-imidazolyl methyl ethers as non-thiol farnesyltransferase inhibitors.

Li Q, Wang GT, Li T, Gwaltney SL 2nd, Woods KW, Claiborne A, Wang X, Gu W, Cohen J, Stoll VS, Hutchins C, Frost D, Rosenberg SH, Sham HL. Li Q, et al. Among authors: wang x, wang gt. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5371-6. doi: 10.1016/j.bmcl.2004.08.011. Bioorg Med Chem Lett. 2004. PMID: 15454229

4

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.

Wang GT, Wang X, Wang W, Hasvold LA, Sullivan G, Hutchins CW, O'Conner S, Gentiles R, Sowin T, Cohen J, Gu WZ, Zhang H, Rosenberg SH, Sham HL. Wang GT, et al. Among authors: wang x, wang w. Bioorg Med Chem Lett. 2005 Jan 3;15(1):153-8. doi: 10.1016/j.bmcl.2004.10.014. Bioorg Med Chem Lett. 2005. PMID: 15582430

5

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Wang GT, Li G, Mantei RA, Chen Z, Kovar P, Gu W, Xiao Z, Zhang H, Sham HL, Sowin T, Rosenberg SH, Lin NH. Wang GT, et al. J Med Chem. 2005 May 5;48(9):3118-21. doi: 10.1021/jm048989d. J Med Chem. 2005. PMID: 15857116

6

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.

Li G, Hasvold LA, Tao ZF, Wang GT, Gwaltney SL 2nd, Patel J, Kovar P, Credo RB, Chen Z, Zhang H, Park C, Sham HL, Sowin T, Rosenberg SH, Lin NH. Li G, et al. Among authors: wang gt. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2293-8. doi: 10.1016/j.bmcl.2006.01.028. Epub 2006 Jan 30. Bioorg Med Chem Lett. 2006. PMID: 16446090

7

Influenza neuraminidase inhibitors: structure-based design of a novel inhibitor series.

Stoll V, Stewart KD, Maring CJ, Muchmore S, Giranda V, Gu YG, Wang G, Chen Y, Sun M, Zhao C, Kennedy AL, Madigan DL, Xu Y, Saldivar A, Kati W, Laver G, Sowin T, Sham HL, Greer J, Kempf D. Stoll V, et al. Biochemistry. 2003 Jan 28;42(3):718-27. doi: 10.1021/bi0205449. Biochemistry. 2003. PMID: 12534284

8

Selective Chk1 inhibitors differentially sensitize p53-deficient cancer cells to cancer therapeutics.

Chen Z, Xiao Z, Gu WZ, Xue J, Bui MH, Kovar P, Li G, Wang G, Tao ZF, Tong Y, Lin NH, Sham HL, Wang JY, Sowin TJ, Rosenberg SH, Zhang H. Chen Z, et al. Int J Cancer. 2006 Dec 15;119(12):2784-94. doi: 10.1002/ijc.22198. Int J Cancer. 2006. PMID: 17019715

9

Design, synthesis, and structural analysis of influenza neuraminidase inhibitors containing pyrrolidine cores.

Wang GT, Chen Y, Wang S, Gentles R, Sowin T, Kati W, Muchmore S, Giranda V, Stewart K, Sham H, Kempf D, Laver WG. Wang GT, et al. Among authors: wang s. J Med Chem. 2001 Apr 12;44(8):1192-201. doi: 10.1021/jm000468c. J Med Chem. 2001. PMID: 11312919

10

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Fidanze SD, Erickson SA, Wang GT, Mantei R, Clark RF, Sorensen BK, Bamaung NY, Kovar P, Johnson EF, Swinger KK, Stewart KD, Zhang Q, Tucker LA, Pappano WN, Wilsbacher JL, Wang J, Sheppard GS, Bell RL, Davidsen SK, Hubbard RD. Fidanze SD, et al. Among authors: wang gt, wang j. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2452-5. doi: 10.1016/j.bmcl.2010.03.015. Epub 2010 Mar 7. Bioorg Med Chem Lett. 2010. PMID: 20346655

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