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Efalizumab (anti-CD11a)-induced increase in peripheral blood leukocytes in psoriasis patients is preferentially mediated by altered trafficking of memory CD8+ T cells into lesional skin.
Vugmeyster Y, Kikuchi T, Lowes MA, Chamian F, Kagen M, Gilleaudeau P, Lee E, Howell K, Bodary S, Dummer W, Krueger JG. Vugmeyster Y, et al. Among authors: krueger jg. Clin Immunol. 2004 Oct;113(1):38-46. doi: 10.1016/j.clim.2004.06.001. Clin Immunol. 2004. PMID: 15380528
The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-gamma, interleukin-2, and tumor necrosis factor-alpha, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients.
Austin LM, Ozawa M, Kikuchi T, Walters IB, Krueger JG. Austin LM, et al. Among authors: krueger jg. J Invest Dermatol. 1999 Nov;113(5):752-9. doi: 10.1046/j.1523-1747.1999.00749.x. J Invest Dermatol. 1999. PMID: 10571730 Free article.
465 results