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A novel approach to specific allergy treatment: the recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity.
Bohle B, Breitwieser A, Zwölfer B, Jahn-Schmid B, Sára M, Sleytr UB, Ebner C. Bohle B, et al. Among authors: zwolfer b. J Immunol. 2004 Jun 1;172(11):6642-8. doi: 10.4049/jimmunol.172.11.6642. J Immunol. 2004. PMID: 15153479
Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1.
Kinaciyan T, Jahn-Schmid B, Radakovics A, Zwölfer B, Schreiber C, Francis JN, Ebner C, Bohle B. Kinaciyan T, et al. Among authors: zwolfer b. J Allergy Clin Immunol. 2007 Apr;119(4):937-43. doi: 10.1016/j.jaci.2006.11.010. Epub 2007 Jan 3. J Allergy Clin Immunol. 2007. PMID: 17204315 Clinical Trial.