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Recombinant modified vaccinia Ankara primes functionally activated CTL specific for a melanoma tumor antigen epitope in melanoma patients with a high risk of disease recurrence.
Smith CL, Dunbar PR, Mirza F, Palmowski MJ, Shepherd D, Gilbert SC, Coulie P, Schneider J, Hoffman E, Hawkins R, Harris AL, Cerundolo V. Smith CL, et al. Among authors: hawkins r. Int J Cancer. 2005 Jan 10;113(2):259-66. doi: 10.1002/ijc.20569. Int J Cancer. 2005. PMID: 15386406 Clinical Trial.
Clinical and immunological responses in metastatic melanoma patients vaccinated with a high-dose poly-epitope vaccine.
Dangoor A, Lorigan P, Keilholz U, Schadendorf D, Harris A, Ottensmeier C, Smyth J, Hoffmann K, Anderson R, Cripps M, Schneider J, Hawkins R. Dangoor A, et al. Among authors: hawkins r. Cancer Immunol Immunother. 2010 Jun;59(6):863-73. doi: 10.1007/s00262-009-0811-7. Epub 2009 Dec 31. Cancer Immunol Immunother. 2010. PMID: 20043222 Free PMC article. Clinical Trial.
CD8 T-cell recognition of human 5T4 oncofetal antigen.
Smyth LJ, Elkord E, Taher TE, Jiang HR, Burt DJ, Clayton A, van Veelen PA, de Ru A, Ossendorp F, Melief CJ, Drijfhout JW, Dermime S, Hawkins RE, Stern PL. Smyth LJ, et al. Int J Cancer. 2006 Oct 1;119(7):1638-47. doi: 10.1002/ijc.22018. Int J Cancer. 2006. PMID: 16646078
Vaccination of colorectal cancer patients with modified vaccinia Ankara delivering the tumor antigen 5T4 (TroVax) induces immune responses which correlate with disease control: a phase I/II trial.
Harrop R, Connolly N, Redchenko I, Valle J, Saunders M, Ryan MG, Myers KA, Drury N, Kingsman SM, Hawkins RE, Carroll MW. Harrop R, et al. Among authors: hawkins re. Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3416-24. doi: 10.1158/1078-0432.CCR-05-2732. Clin Cancer Res. 2006. PMID: 16740766 Clinical Trial.
Engineering T cells for cancer therapy.
Mansoor W, Gilham DE, Thistlethwaite FC, Hawkins RE. Mansoor W, et al. Among authors: hawkins re. Br J Cancer. 2005 Nov 14;93(10):1085-91. doi: 10.1038/sj.bjc.6602839. Br J Cancer. 2005. PMID: 16251873 Free PMC article. Review.
Vaccination of colorectal cancer patients with TroVax given alongside chemotherapy (5-fluorouracil, leukovorin and irinotecan) is safe and induces potent immune responses.
Harrop R, Drury N, Shingler W, Chikoti P, Redchenko I, Carroll MW, Kingsman SM, Naylor S, Griffiths R, Steven N, Hawkins RE. Harrop R, et al. Among authors: hawkins re. Cancer Immunol Immunother. 2008 Jul;57(7):977-86. doi: 10.1007/s00262-007-0428-7. Cancer Immunol Immunother. 2008. PMID: 18060404 Free PMC article. Clinical Trial.
2,158 results