Enzymatic activity of 2'-5'-oligoadenylate synthetase is impaired by specific mutations that affect oligomerization of the protein.
Ghosh A, Sarkar SN, Guo W, Bandyopadhyay S, Sen GC.
Ghosh A, et al.
J Biol Chem. 1997 Dec 26;272(52):33220-6. doi: 10.1074/jbc.272.52.33220.
J Biol Chem. 1997.
PMID: 9407111
Free article.
Previous studies from our laboratory have shown that deletion of residues 321 to 344 of the 9-2 isozyme of 2'-5'-oligoadenylate (2-5(A)) synthetase causes a loss of its enzyme activity (Ghosh, S. K., Kusari, J., Bandyopadhyay, S. ...These results indicate tha …
Previous studies from our laboratory have shown that deletion of residues 321 to 344 of the 9-2 isozyme of 2'-5'-oligoadenylate (2-5(A …